Summary
Investigations have been made with rabbits to indicate some disturbances in the living organism brought by hydrogen sulfide (H2S) about poisoning and to see if administration of some trace metals present in Vitaral has any effect upon these disturbances.
In the course of the investigation protein, enzymatic and mineral disturbances as well as acid-base balance disorders were found. The disturbances did not occur when the exposed rabbits received Vitaral with their food.
The investigations were made in order to determine how H2S exerts its poisonous action upon the brain, kidney, heart and liver. The H2S mechanism is based on its ability to bind with alkali metals which, among others, play an important role as activators of some of the enzymes. As a result of the binding, the enzymes are deprived of their metal activators.
This accounts for the inhibition of the examined enzymes. Vitaral administered to the poisoned animals substituted the lacking trace metals which was followed by reactivation of the disturbed enzymes.
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KoŚmider, S., Rogala, E., Dwornicki, J. et al. The influence of vitaral on some mineral and enzyme disturbances in subacute poisoning with hydrogen sulfide. Int. Arch. Arbeitsmed 29, 64–84 (1971). https://doi.org/10.1007/BF00539029
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DOI: https://doi.org/10.1007/BF00539029