Summary
The inhalation toxicity of dimethylformamide (DMF) to female SD rats was histopathologically studied. Although the solvent obviously injured the liver, no abnormality was found morphologically in other organs. Hepatotoxicity was, on the whole, more remarkably observed in young rats than in adult ones. In young female rats histological alteration caused by exposure to DMF was influenced by the age of the rats, one day's exposure time, total exposed days, and the capacity of liver cells to regenerate. DMF was found to be less toxic than carbon tetrachloride in these rats.
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References
Clayton, J. W., Barnes, J. R., Hood, D. B., Schepers, G. W. H.: The inhalation toxicity of dimethylformamide (DMF). Amer. industr. Hyg. Ass. J. 24, 144–154 (1963).
Hoffman, J., Himes, M. B., Lapan, S., Riszki, R., Post, J.: Responses of the liver to injury; effects of acute carbon tetrachloride poisoning. Arch. Path. 59, 429–438 (1955).
Hofmann, H. T.: Zur Frage der hepatotoxischen Wirkung von Dimethylformamid. Naunyn-Schmiedebergs Arch. exp. Path. Pharmak. 240, 38–39 (1960).
Massmann, W.: Toxicological investigations on dimethylformamide. Brit. J. industr. Med. 13, 51–54 (1956).
McClosky, J. F., McGehee, E. H.: Effect of subcutaneous and intraoral administration of carbon tetrachloride on the liver of the rat. Arch. Path. 49, 200–204 (1950).
Smyth, H. F., Carpenter, C. P.: Further experience with the range finding test in the industrial toxicology laboratory. J. industr. Hyg. 30, 63–68 (1948).
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Tanaka, Ki. Toxicity of dimethylformamide (DMF) to the young female rat. Int. Arch. Arbeitsmed 28, 95–105 (1971). https://doi.org/10.1007/BF00539018
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DOI: https://doi.org/10.1007/BF00539018