Mammalian Genome

, Volume 6, Issue 11, pp 802–804 | Cite as

Refined mapping of caltractin in human Xq28 and in the homologous region of the mouse X Chromosome places the gene within the bare patches (Bpa) and striated (Str) critical regions

  • A. Chatterjee
  • T. Tanaka
  • J.E. Parrish
  • G.E. Herman
Original Contributions


Caltractin belongs to a family of calcium-binding proteins and is a structural component of the centrosome. A human caltractin cDNA (CALT) has recently been mapped by fluorescence in situ hybridization (FISH) to Xq28. We report here refined mapping of the human CALT gene and its murine homolog between the loci DXS1104 (DXHXS1104) and DXS52 (DXHXS52) by PCR and Southern analysis of YACs and somatic cell hybrids from the region in both species. These mapping studies place the gene within the critical region for the murine X-linked dominant, male lethal mutations bare patches and striated.


Somatic Cell Structural Component Critical Region Mapping Study Cell Hybrid 
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Copyright information

© Springer-Verlag New York Inc. 1995

Authors and Affiliations

  • A. Chatterjee
    • 1
  • T. Tanaka
    • 2
    • 3
  • J.E. Parrish
    • 1
  • G.E. Herman
    • 1
  1. 1.Department of Molecular and Human Genetics, One Baylor Plaza 821TBaylor College of MedicineHoustonUSA
  2. 2.Laboratory of Molecular Medicine, Institute of Medical Science, Faculty of MedicineUniversity of TokyoTokyoJapan
  3. 3.The Third Department of Internal Medicine, Faculty of MedicineUniversity of TokyoTokyoJapan

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