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Reciprocal metabolic inhibition of toluene and trichloroethylene in vivo and in vitro

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Summary

Administration of trichloroethylene to rats in addition to toluene suppressed the urinary excretion of hippuric acid, a main metabolite of the aromatic compound. Reversely, when co-administered with trichloroethylene, toluene reduced the amount of urinary total trichloro-compounds, the metabolites of the chlorinated ethylene. Kinetic approach in vitro to this reciprocal metabolic suppression revealed that trichloroethylene is a non-competitive inhibitor of side-chain hydroxylation of p-nitrotoluene, a substrate analogue of toluene, and toluene, in turn, inhibits oxidation of trichloroethylene non-competitively. Toxicological significance of this observation as well as circumspection in biological monitoring of organic solvent exposure in relation to metabolic suppression are briefly discussed.

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Authors and Affiliations

  1. Department of Public Health, Kyoto University Faculty of Medicine, Kyoto

    Masayuki Ikeda

  2. Department of Hygiene, Tohoku University School of Medicine, Sendai, Japan

    Masayuki Ikeda

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  1. Masayuki Ikeda
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This work was supported in part by a research grant from the Fujiwara Memorial Foundation.

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Ikeda, M. Reciprocal metabolic inhibition of toluene and trichloroethylene in vivo and in vitro . Int. Arch. Arbeitsmed 33, 125–130 (1974). https://doi.org/10.1007/BF00538996

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  • DOI: https://doi.org/10.1007/BF00538996

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