Summary
1. The effect of “antigastrin” (SC-15 396) on gastric acid and pepsin secretion produced by the gastrin-analogue tetrapeptide amide Try. Met. Asp. Phe-NH2 and by electrical stimulation of the vagus was investigated in anaesthetized gastric fistula cats.
2. “Antigastrin” failed to inhibit both acid and pepsin response stimulated by either the tetrapeptide or vagus excitation.
3. It was concluded that the ineffectiveness of “antigastrin” in cats is due to a species difference between rats and dogs on the one hand and cats on the other, and that “antigastrin” is not a specific gastrin antagonist.
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Supported by the Deutsche Forschungsgemeinschaft and by the Alfred Teufel-Stiftung.
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Sewing, K.F., Gorinsky, P.D. & Lembeck, F. Failure of “antigastrin” (SC-15 396) to inhibit gastric acid and pepsin secretion in anaesthetized gastric fistula cats. Naunyn-Schmiedebergs Arch. Pharmak. u. Exp. Path. 261, 89–92 (1968). https://doi.org/10.1007/BF00537870
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DOI: https://doi.org/10.1007/BF00537870