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The action of adrenal steroids on the pharmacological reactivity of the isolated vein of the rabbit ear

  • J. D. Horowitz
  • M. L. Mashford
Article
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Summary

1. The isolated perfused central vein of the rabbit ear has been used to investigate potentiation by adrenal steroids of the actions of bradykinin, histamine and noradrenaline.

2. Potentiation of all substances occurred when adrenal steroids in large doses were added to the perfusate but was neither large in magnitude nor constant in occurrence. Potentiation was seen with cortisol and dexamethasone and their potency was in the same relationship as their glucocorticoid activity. However aldosterone was roughly equi-potent with dexamethasone.

3. Thus the potentiation by steroids in this preparation is non-specific in that BK and histamine as well as noradrenaline responses are affected. The potency of steroids does not parallel either glucocorticoid or mineralocorticoid activity and so these results do not suggest an effect of steroids on either specific receptors or membrane electrolyte distribution.

Key-Words

Catecholamines Plasma Kinins Histamine Glucocorticoid Aldosterone 

Schlüsselwörter

Brenzcatechinamin Plasmakinin Histamin Glucocorticoid Aldosteron 

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Copyright information

© Springer-Verlag 1969

Authors and Affiliations

  • J. D. Horowitz
    • 1
  • M. L. Mashford
    • 1
    • 2
  1. 1.Department of Human Physiology and PharmacologyUniversity of Adelaide
  2. 2.Department of Medicine Austin HospitalUniversity of MelbourneHeidelbergAustralia

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