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Induced drug release from lipid vesicles in serum by pH-change

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Abstract

Drugs can be released from lipid vesicles by pH-change in calf, horse or human serum when pH-sensitive trigger molecules are incorporated in the vesicle lipid bilayer. The lipid composition is so chosen that the drug release is best performed at 37‡ C. Specific drug targeting is envisaged to loci of the body with lower than physiological pH, such as primary or metastatic tumors.

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References

  • Kreutz W (1972) Structural principles of biomembranes. Angew Chemie (Int. Ed.) 11(7): 551–567

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Author notes

  1. M. B. Yatvin

    Present address: Department of Human Oncology, University of Wisconsin, Madison, WI, USA

Authors and Affiliations

  1. Department of Membrane Research, Weizmann Institute, Rehovot, Israel

    M. B. Yatvin, W. Kreutz, B. Horwitz & M. Shinitzky

  2. Institut für Biophysik und Strahlenbiologie der Universität Freiburg, Albertstra\e 23, D-7800, Freiburg, Germany

    M. B. Yatvin, W. Kreutz, B. Horwitz & M. Shinitzky

Authors
  1. M. B. Yatvin
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  2. W. Kreutz
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  3. B. Horwitz
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  4. M. Shinitzky
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Additional information

Recipient of Senior International Fellowship FO6-TW 00325 of the Fogarty International Center, National Institute of Health.

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Yatvin, M.B., Kreutz, W., Horwitz, B. et al. Induced drug release from lipid vesicles in serum by pH-change. Biophys. Struct. Mechanism 6, 233–234 (1980). https://doi.org/10.1007/BF00537296

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  • DOI: https://doi.org/10.1007/BF00537296

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