Summary
Strain specific round cell carcinoma (so called BO-tumors) were induced in CBA mice by heteroinduction. The tumors have a hypotetraploid set of 72 chromosomes and a tetraploid DNA stemline. There is a deviation of the mean DNA content of a tumorchromosome of about 20%. Some methodical reasons for this deviation are discussed.
Zusammenfassung
Durch Heteroinduktion entwickelten sich bei CBA-Mäusen stammesspezifische rundzellige Carcinome (sog. BO-Tumoren). Cytogenetische Untersuchungen ergeben einen Modalwert von 72 Chromosomen, die cytophotometrisch ermittelte DNS-Stammlinie liegt im tetraploiden Bereich. Die Tumorchromosomen besitzen daher einen um ca. 20% höheren mittleren DNS-Gehalt. Methodische Fehlermöglichkeiten werden diskutiert.
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Filkuka, J., Adámek, R. & Lederer, B. Chromosomenzahl und DNS-Gehalt eines übertragbaren rundzelligen Mäusecarcinoms (BO-Tumor). Z Krebs-forsch 70, 236–240 (1968). https://doi.org/10.1007/BF00536997
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DOI: https://doi.org/10.1007/BF00536997