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The role of N,N-dimethylaniline-N-oxide in the formation of hemiglobin following the absorption of N,N-dimethylaniline

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Summary

Since the concentrations of phenylhydroxylamine and nitrosobenzene in the blood of cats and dogs are too low to produce all the hemiglobin observed following the injection of N,N-dimethylaniline, other meta-bolites were tested for their hemiglobin forming activity.

After the intravenous injection of 0.6 mMol N,N-dimethylaniline or N,N-diethylaniline per kg into dogs the hemiglobin concentration rose beyond 0.4 of the total blood pigment, and the N-oxides were found in the blood of dogs in concentrations of about 8 and 6 μg/ml. These concentrations of the N-oxides in the blood of dogs, when produced by intravenous infusion of the N-oxides, did not raise the hemiglobin concentration. Therefore, the N-oxides are not the metabolites that form the hemiglobin observed after the absorption of N,N-dialkylanilines.

p-Dimethylaminophenol, a metabolite of N,N-dimethylaniline, was found to be highly active in forming hemiglobin in vitro and in vivo. It is likely that it plays an important role in the hemiglobin formation following the absorption of N,N-dimethylaniline.

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Authors and Affiliations

  1. Pharmakologisches Institut der Universität München, Germany

    Manfred Kiese, Elli Rauscher & Nikolaus Weger

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  1. Manfred Kiese
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  2. Elli Rauscher
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  3. Nikolaus Weger
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Kiese, M., Rauscher, E. & Weger, N. The role of N,N-dimethylaniline-N-oxide in the formation of hemiglobin following the absorption of N,N-dimethylaniline. Naunyn-Schmiedebergs Arch. Pharmak. u. Exp. Path. 254, 253–260 (1966). https://doi.org/10.1007/BF00536223

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  • DOI: https://doi.org/10.1007/BF00536223

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