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Über die Wirkung von Morphin und Apomorphin auf die respiratorische Glottisinnervation der Ratte

  • T. Kuga
  • W. D. Erdmann
Article

Summary

The effect of morphine and apomorphine on the electrical activity of the efferent recurrent laryngeal and phrenic nerves has been investigated in anaesthetized rats.

1. Morphine caused an excessive excitation in the efferent N. recurrens vagi. A complete recovery could be observed within 5 min. When repeated doses were injected tachyphylaxis occurred. It has been proven on single nerve fibre preparations that the excitation of the recurrent nerve is caused by a central stimulation of exspiratory active neurons.

2. Apomorphine also caused an excessive excitation in the recurrent nerve, but this effect is permanent for 60–90 min. Tachyphylaxis was not observed. The excitation of the recurrent nerve is caused by a stimulation of so-called tonic neurons in this nerve. Short periods of exspiratory stimulation occur in different time intervals.

The results obtained present no evidence for an esterase inhibiting mechanism of morphine or apomorphine. It is possible, however, that in the rat the exspiratory stimulation in the recurrent nerve is equivalent to an emetic response to these drugs.

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Copyright information

© Springer-Verlag 1966

Authors and Affiliations

  • T. Kuga
    • 1
  • W. D. Erdmann
    • 1
  1. 1.Pharmakologisches Institut der Universität GöttingenGermany

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