Abstract
The sodium salt of 4-hydroxy-6-methyl-2-methylthiopyrimidine is alkylated with chloroacetonitrile in hexamethyltriamidophosphate on the O-atom, and in dioxane or tetrahydrofuran on the N3-atom, with the formation of 6-methyl-2-methylthio-4-cyanomethoxypyrimidine and 6-methyl-2-methylthio-3-cyanomethyl-4-pyrimidone, respectively.
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 11, pp. 1525–1527, November, 1992.
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Syadyaryavichyute, V., Vainilavichyus, P. Alkylation of 4-hydroxy-6-methyl-2-methylthio-pyrimidine with chloroacetonitrile. Chem Heterocycl Compd 28, 1304–1306 (1992). https://doi.org/10.1007/BF00532083
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DOI: https://doi.org/10.1007/BF00532083