Chemistry of Heterocyclic Compounds

, Volume 29, Issue 11, pp 1335–1339 | Cite as

Synthesis and some properties of 6-β-oxoalkyl(aralkyl, hetaralkyl, cycloalkyl)thiopurines

  • P. M. Kochergin
  • M. Yu. Gromov
  • E. V. Aleksandrova
  • S. Ya. Skachilova


The reaction of 6-purinethione with α-haloketones has given a series of new 6-β-oxoalkyl(aralkyl, hetaralkyl, cycloalkyl)thiopurines. Their alkylation in position 9 and acid hydrolysis to hypoxanthine and its 9-alkyl derivatives has been studied. The hydrolysis of the acetals of 6-formylmethylthiopurine and the oxidation of 6-(2,3-dihydroxypropyl)thiopurine leads to 6-formylmethylthiopurine, which shows a ring-chain tautomerism and exists in the form of 7-hydroxy-7,8-dihydrothiazolo[2,3-i]purine.


Oxidation Acetal Hydrolysis Organic Chemistry Alkylation 
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Copyright information

© Plenum Publishing Corporation 1994

Authors and Affiliations

  • P. M. Kochergin
    • 1
    • 2
    • 3
  • M. Yu. Gromov
    • 1
    • 2
    • 3
  • E. V. Aleksandrova
    • 1
    • 2
    • 3
  • S. Ya. Skachilova
    • 1
    • 2
    • 3
  1. 1.Center for Chemistry of DrugsAll-Russian Scientific-Research Chemical and Pharmaceutical InstituteMoscow
  2. 2.All-Russian Scientific Center for the Safety of Biologically Active SubstancesStaraya KupavnaMoscow Region
  3. 3.Zaporozh'e Medical InstituteZaporozh'e

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