Zeitschrift für Krebsforschung

, Volume 63, Issue 2, pp 184–208 | Cite as

Cytological studies of tumors, XXVII. The chromosomes of thirty human tumors

  • Sajiro Makino
  • Takaaki Ishihara
  • Akira Tonomura


The chromosome conditions were investigated in thirty cases of primary human tumors in two types of material, solid and effusion, by the use of the water-pretreatment squash method.

The number of chromosomes of human tumors shows a pronounced variation within a wide range, but there is always present in each tumor a stem-line (or lines) of tumor cells occurring most frequently with a characteristic number-mode (or modes) different from the normal number, and a specific idiogram (or idiograms) clearly distinguishable from those of other tumors as well as from that of normal tissue. There are indications that together with the numerical changes of chromosomes, the human tumors might have undergone many possible structural and mutational changes of the stemline chromosomes.

The tumors investigated here exhibit a variety of stemline chromosome numbers. The tumors characterized by hyperdiploid stemline number are most frequent amongst thirty cases studied.

Different tumors which originated from the same organ are characterized by different stemline chromosome patterns. This seems to suggest that the genetic pattern which is closely correlated with the property of the tumor may not be identical in each tumor, even though they originated from the same organ.


Public Health Tumor Cell Cancer Research Normal Tissue Chromosome Number 
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Untersucht wurde das Verhalten der Chromosomen bei 30 menschlichen Tumoren, die teils in der soliden Form vorlagen, teils wurden Tumorzellen aus Exsudaten untersucht. Die Chromosomenzahl zeigte eine große Variationsbreite. In jedem Tumor sind aber eine oder mehrere Stammlinien von am häufigsten vorkommenden Zellen nachweisbar mit einer von der Normalzelle abweichenden charakteristischen Chromosomenzahl und einem spezifischen Idiogramm, das sich deutlich von dem anderer Tumoren wie auch von dem anderer Zellen unterscheidet. Am häufigsten sind hyperdiploide Chromosomensätze. Verschiedene Tumoren desselben Organs sind durch ein verschiedenes Chromosomenmuster der Stammlinien gekennzeichnet.

Offenbar haben Tumoren zugleich mit den zahlenmäßigen Veränderungen der Chromosomen auch strukturelle Veränderungen und Mutationen der Chromosomen mitgemacht.


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Copyright information

© Springer-Verlag 1959

Authors and Affiliations

  • Sajiro Makino
    • 1
  • Takaaki Ishihara
    • 1
  • Akira Tonomura
    • 1
  1. 1.Zoological InstituteHokkaido UniversitySapporoJapan

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