Synthesis and recyclization of 6-benzyl-3a,4,5,6,7,7a-hexahydro-3a-hydroxy-7a-methyl-2-thioxo-5-phenyloxazolo[5,4-c]pyridines
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The corresponding oxazolo[5,4-c]pyridines were obtained in the reaction of stereoisomeric 1-benzyl-3-hydroxy-3-methyl-6-phenyl-4-piperidines with potassium thiocyanate in acetic acid and rearranged into 6-benzyl-5,6,7,8-tetrahydro-1-methyl-3-thioxo-7-phenyloxazolo[3,4-c]pyrimidine by boiling in o-xylene. It was shown that the rearrangement is reversible.
KeywordsAcetic Potassium Acetic Acid Organic Chemistry Pyridine
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