Zeitschrift für Krebsforschung

, Volume 74, Issue 4, pp 383–389 | Cite as

On the biochemical mechanism of tumorigenesis in mouse skin

III. Decrease in tumor yields by poly I/C administered during initiation of skin by an intragastric dose of 7,12-dimethyl-benz[a]anthracene
  • G. Kreibich
  • R. Süss
  • V. Kinzel
  • E. Hecker
Article

Summary

Intraperitoneal injections of polyinosinic acid/polycytidylic acid (poly I/C) reduce the tumor yields in Berenblum-experiments, if the synthetic, double-stranded ribonucleic acid is administered during tumor initiation of mouse skin by intragastric application of 7,12-dimethylbenz[a]anthracene. A reduction of tumor yield is not observed, if similar poly I/C treatment is scheduled before or during tumor promotion induced by topically administered phorbol ester TPA.

Keywords

Public Health Ester Cancer Research Intraperitoneal Injection Phorbol 

Zusammenfassung

Intraperitoneale Injektionen von Polyinosinsäure/Polycytidylsäure (Poly I/C) vermindern die Tumorausbeuten im Berenblum-Experiment, wenn die synthetische doppelsträngige Ribonucleinsäure während der Initiierungsphase der Mäusehaut—induziert durch intragastral verfüttertes 7,12-Dimethylbenz[a]anthracen — appliziert wird. Eine Verminderung der Tumorausbeuten durch ähnliche Poly I/C-Behandlung vor oder während der Promotionsphase — induziert auch topisch applizierten Phorbolester TPA — wird nicht beobachtet.

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Copyright information

© Springer-Verlag 1970

Authors and Affiliations

  • G. Kreibich
    • 1
    • 2
  • R. Süss
    • 1
    • 2
  • V. Kinzel
    • 1
    • 2
  • E. Hecker
    • 1
    • 2
  1. 1.Institute of BiochemistryGerman Cancer Research CenterHeidelbergGermany
  2. 2.Institute of Experimental PathologyGerman Cancer Research CenterHeidelbergGermany

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