Abstract
It has been shown for melanostatin analogs that the energy of the HOMO, calculated by the CNDO/2 method for side substitutents of the second amino acid residue, is correlated with the antidepressive activity. The excessive electron density that appears in the peptide chain is delocalized on the MO of the substituent to which the AO of the first carbon atom makes the greatest contribution (LUMO).
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References
Yu. E. Shapiro, V. Ya. Gorbatyuk, V. M. Kabanov, et al., Bioorgan. Khim., 6, No. 12, 1607–1617 (1990).
A. A. Mazurov, S. A. Andronati, V. M. Kabanov, et al., Collect. Czech. Chem. Commun., 55, 2555–2561 (1990).
A. A. Mazurov, S. A. Andronati, B. A. Lobasyuk, et al., Khim.-farm. Zh., No. 2, 155–158 (1988).
A. N. Vereshchagin, The Inductive Effect. Substituent Constants for Correlation Analysis [in Russian], Nauka, Moscow (1988).
C. Coulson, Valency [Russian translation], Mir, Moscow (1965).
W. Burkert and N. L. Allinger, Molecular Mechanics [Russian translation]. Mir, Moscow (1986), p. 65.
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Translated from Teoreticheskaya i Éksperimental'naya Khimiya, Vol. 29, No. 3, pp. 255–259, May–June, 1993.
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Shapiro, Y.E., Gorbachev, M.Y., Gorbatyuk, V.Y. et al. Influence of the second amino acid residue on the antidepressive activity of melanostatin analogs. Theor Exp Chem 29, 173–175 (1994). https://doi.org/10.1007/BF00531177
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DOI: https://doi.org/10.1007/BF00531177