Skip to main content
SpringerLink
Log in

Mechanism of the antitumor action of complex compounds of copper(II) with α-amino acids

  • Published:
Theoretical and Experimental Chemistry Aims and scope

Abstract

It is shown theoretically and experimentally that the high superoxide dismutase-like activity of certain amino acids and their CuA2 and CuAB complexes does not correlate with antitumor activity. It was found that the difference in activity is connected with the electronic structure, which explains the dependence of activity on the structure of the complex and the nature of its ligands.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. E. M. Treshchalina, N. V. Matveichuk (Andronova), N. O. Gudratov, and G. I. Potapova, Byull. Éksp. Biol. Med., 99, No. 1, 86–88 (1985).

    Google Scholar 

  2. S. S. Budnikov, S. V. Donu, L. F. Chapurina, et al., Teor. Éksp. Khim., 3, No. 3, 351–356 (1985).

    Google Scholar 

  3. L. F. Chapurina, I. A. D'yakov, S. V. Donu, and S. S. Budnikov, Problems of Contemporary Bioinorganic Chemistry, [in Russian], Nauka, Novosibirsk (1986).

    Google Scholar 

  4. E. E. Kriss, I. I. Volchenskova, A. S. Grigor'eva, et al., Coordination Compounds in Medicine [in Russian], Naukova Dumka, Kiev (1986).

    Google Scholar 

  5. L. S. Vartanyan and S. M. Gurevich, Vopr. Med. Khim., 28, No. 5, 23–26 (1982).

    Google Scholar 

  6. L. W. Oberley and G. R. Buettner, Cancer Research, 39, No. 4, 141–1149 (1979).

    Google Scholar 

  7. E. M. Treshchalina, A. L. Konovalova, M. A. Presnov, et al., Dokl. Akad. Nauk SSSR, 248, No. 5, 1273–1276 (1979).

    Google Scholar 

  8. S. S. Budnikov and F. A. Spatar', Teor. Éksp. Khim., 2, No. 2, 219–225 (1980).

    Google Scholar 

  9. S. S. Budnikov, “Electron redistributions and vibron effects in molecules upon addition to complexes of transition metals,” Author's Abstract of Doctoral Dissertation, Moscow (1990).

Download references

Author information

Authors and Affiliations

  1. Institute of Chemistry, Academy of Sciences of Moldova, Kishinev

    L. F. Chapurina, S. S. Budnikov, S. M. Gurevich & L. G. Nagler

Authors
  1. L. F. Chapurina
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. S. S. Budnikov
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. S. M. Gurevich
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. L. G. Nagler
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

Translated from Teoreticheskaya i Éksperimental'naya Khimiya, Vol. 29, No. 3, pp. 233–238, May–June, 1993.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Chapurina, L.F., Budnikov, S.S., Gurevich, S.M. et al. Mechanism of the antitumor action of complex compounds of copper(II) with α-amino acids. Theor Exp Chem 29, 158–161 (1994). https://doi.org/10.1007/BF00531173

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00531173

Keywords

Search

Navigation