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Immunchemische Differenzierung γG-monoclonaler und polyclonaler Gammopathien durch Elektroimmundiffusion

Immunochemical differentiation of γG-monoclonal and polyclonal gammopathies by electroimmuno-diffusion

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Abstract

Abnormal and normal γG-globulins in γG-monoclonal gammopathies can be distinguished qualitatively and semiquantitatively by electroimmuno-diffusion. The exact quantitative determination of the normal γG-globulin is possible, only in cases with sufficiently different electrophoretic mobility between both components. Applicability and limits of the method are discussed regarding examples of γG-globulin determinations in normal serum and in sera from patients with monoclonal and polyclonal gammopathies.

Zusammenfassung

Die Elektroimmundiffusion erlaubt bei γG-monoclonalen Gammopathien die qualitative und semiquantitative Differenzierung von Paraund Normalproteinen der gleichen Immunglobulinklasse. Die exakte quantitative Bestimmung der nicht paraproteinämischen Komponente ist möglich bei genügend großem Unterschied in der elektrophoretischen Beweglichkeit beider γG-Globuline. An Beispielen von γG-Globulinbestimmungen in Normalserum und Seren von Patienten mit monoclonalen und polyclonalen Gammopathien werden Brauchbarkeit und Grenzen der Methode diskutiert.

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Authors and Affiliations

  1. Behringwerke AG, Marburg/Lahn

    W. Becker

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  1. W. Becker
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Becker, W. Immunchemische Differenzierung γG-monoclonaler und polyclonaler Gammopathien durch Elektroimmundiffusion. Z. Anal. Chem. 243, 442–447 (1968). https://doi.org/10.1007/BF00530723

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  • DOI: https://doi.org/10.1007/BF00530723

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