Chemistry of Heterocyclic Compounds

, Volume 28, Issue 10, pp 1185–1188 | Cite as

Synthesis of 1-substituted dihydropyrimidinone and quinazolinone derivatives

  • V. Yu. Mitskyavichyus
  • R. S. Baltrushis


Condensation of N-substituted β-alanines (synthesized from anthranilic acid or its esters and acrylic acid) with urea afforded the corresponding 1-substituted dihydropyrimidinedione and quinazolinedione. When potassium thiocyanate was employed in the reaction instead of urea, decarboxylation and desulfuration occurred.


Ester Potassium Urea Organic Chemistry Acrylic Acid 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    V. Yu. Mitskyavichyus, R. S. Baltrushis, and Z.-I. G. Beresnevichyus, Khim. Geterotsikl. Soedin., No. 4, 534 (1991).Google Scholar
  2. 2.
    F. Lengfeld and Stieglitz, J. Amer. Chem. Soc., 15, 504 (1893).Google Scholar
  3. 3.
    B. Kurtev, M. Lyapova, N. Berova, I. Pozharliev, A. Orakhovats, P. Petrova, and N. Mollov, Izv. Otd. Khim. Nauk Bolg. Akad. Nauk, 1, 51 (1968).Google Scholar
  4. 4.
    Z. F. Solomko, M. S. Malinovskii, L. N. Polovina, and V. I. Gorbatenko, Khim. Geterotsikl. Soedin., No. 3, 536 (1969).Google Scholar
  5. 5.
    R. S. Baltrushis, Z.-I. G. Beresnevichyus, and V. Yu. Mitskyavichyus, Khim. Geterotsikl. Soedin., No. 10, 1400 (1982).Google Scholar
  6. 6.
    C. D. Hurd and S. Hayao, J. Amer. Chem. Soc., 74, 5889 (1952).Google Scholar

Copyright information

© Plenum Publishing Corporation 1993

Authors and Affiliations

  • V. Yu. Mitskyavichyus
    • 1
  • R. S. Baltrushis
    • 1
  1. 1.Kaunas University of TechnologyKaunas

Personalised recommendations