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Zeitschrift für Krebsforschung

, Volume 62, Issue 4, pp 408–418 | Cite as

Some data in anti-cancer experiments

  • H. Okamoto
  • S. Koshimura
  • R. Hirata
  • K. Murasawa
  • Y. Bando
  • R. Shimizu
Article

Keywords

Public Health Cancer Research 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Zusammenfassung

Die Bildung von Streptolysin-S durch den Streptococcus haemolyticus wird durch Zugabe von Nucleinsäure gesteigert. Die hemmende Wirkung von hämolysierenden Streptokokken auf Ehrlich-Ascitescarcinom und Yoshida-Ascitessarkom ist dadurch zu erklären, daß die Keime auf Kosten der in den Tumorzellen enthaltenen Ribonucleinsäure Streptolysin bilden. Anderen Keimen (s. Tabelle 2) fehlt diese Eigenschaft. Auf einschlägige alte Beobachtungen an Menschen wird hingewiesen.

Da chemische Stoffe, welche die Hämolysin-S-Bildung durch Streptokokken vermindern oder gar aufheben, dies dadurch tun, daß sie in den auch für das Wachstum der Tumorzellen wichtigen Ribonucleinsäure-Stoffwechsel eingreifen, wurde unter derartigen Stoffen nach anticancerös wirkenden Mitteln gesucht und ein sehr wirksames (Azo 106) gefunden.

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Copyright information

© Springer-Verlag 1958

Authors and Affiliations

  • H. Okamoto
    • 1
  • S. Koshimura
    • 1
  • R. Hirata
    • 1
  • K. Murasawa
    • 1
  • Y. Bando
    • 1
  • R. Shimizu
    • 1
  1. 1.Research Institute of Tuberculosis, and Department of Pharmacology, School of MedicineKanazawa UniversityJapan

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