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Some data in anti-cancer experiments

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Zusammenfassung

Die Bildung von Streptolysin-S durch den Streptococcus haemolyticus wird durch Zugabe von Nucleinsäure gesteigert. Die hemmende Wirkung von hämolysierenden Streptokokken auf Ehrlich-Ascitescarcinom und Yoshida-Ascitessarkom ist dadurch zu erklären, daß die Keime auf Kosten der in den Tumorzellen enthaltenen Ribonucleinsäure Streptolysin bilden. Anderen Keimen (s. Tabelle 2) fehlt diese Eigenschaft. Auf einschlägige alte Beobachtungen an Menschen wird hingewiesen.

Da chemische Stoffe, welche die Hämolysin-S-Bildung durch Streptokokken vermindern oder gar aufheben, dies dadurch tun, daß sie in den auch für das Wachstum der Tumorzellen wichtigen Ribonucleinsäure-Stoffwechsel eingreifen, wurde unter derartigen Stoffen nach anticancerös wirkenden Mitteln gesucht und ein sehr wirksames (Azo 106) gefunden.

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References

  1. Greenstein, J. P., and A. Haddow: Advances in cancer research, vol. 1–4. New York: Academic Press 1953–1956.

    Google Scholar 

  2. Greenstein, J. P.: Biochemistry of cancer, 2. edit. New York: Academic Press 1954.

    Google Scholar 

  3. Okamoto, H.: Über die hochgradige Steigerung des Hämolysinbildungsvermögens des Streptococcus haemolyticus durch Nucleinsäure. I. Mitt. Jap. J. med. Sci., IV. Pharmacol. 12, 167 (1940).

    Google Scholar 

  4. Bernheimer, A. W., and M. Rodbart: The effect of nucleic acids and of carbohydrates on the formation of streptolysin. J. exp. Med. 88, 149 (1948).

    Google Scholar 

  5. Bernheimer, A. W.: Formation of a bacterial toxin (Streptolysin S) by resting cells. J. exp. Med. 90, 373 (1949).

    Google Scholar 

  6. Bernheimer, A. W.: Stabilization of Streptolysin S by potassium ions. J. exp. Med. 92, 129 (1950).

    Google Scholar 

  7. Cinader, B., and L. Pillemer: The purification and properties of Streptolysin S. J. exp. Med. 92, 219 (1950).

    Google Scholar 

  8. Hosoya, S., T. Hayashi, Y. Mori, F. Egami, M. Shimomura and Y. Yagi: The hemolysin obtained from the nucleic acid added broth culture of hemolytic streptococci. Jap. J. exp. Med. 20, 25 (1949).

    Google Scholar 

  9. Hosoya, S., T. Hayashi, Y. Homma, F. Egami, M. Shimomura and Y. Yagi: The hemolysin obtained by shaking a mixture of hemolytic streptococci with nucleic acid solution. Jap. J. exp. Med. 20, 27 (1949).

    Google Scholar 

  10. Egami, F., M. Shimomura, Y. Yagi, T. Hayashi, T. Mase and S. Hosoya: The hemolysin obtained by incubating a mixture of hemolytic streptococci with nucleic acid solution. Jap. J. exp. Med. 20, 527 (1950).

    Google Scholar 

  11. Okamoto, H., S. Kyoda u. R. Ito: Weitere Ergebnisse der Untersuchung zur Darstellung hochgereinigter Streptolysinpräparate. Jap. J. med. Sci., IV. Pharmacol. 14, 99 (1941).

    Google Scholar 

  12. Okamoto, H., K. Matsuda, u. S. Kyoda: Chemische Untersuchungen an hochgereinigter Streptolysinfraktion. Folia pharmacol. jap. 33, 370 (1941).

    Google Scholar 

  13. Matsuda, K.: Untersuchungen über die pharmakologischen Eigenschaften des Streptolysin. Folia pharmacol. jap. 36, 171 (1942).

    Google Scholar 

  14. Shimizu, R.: Studies on the capability of yeast ribonucleic acid to transfer silver salt into a non-ionized form. J. pharmaceut. Soc. Jap. 76, 158 (1956).

    Google Scholar 

  15. Shoin, S.: On the stabilizing effect of silver salts upon Streptolysin S. Jap. J. exp. Med. 24, 13 (1954).

    Google Scholar 

  16. Tanaka, K., S. Maekawa, T. Hayashi and Y. Kuroiwa: Effects of alkali-treated ribonucleic acid in the hemolysin formation. J. Biochem. (Tokyo) 43, 827 (1956).

    Google Scholar 

  17. Tanaka, K., S. Maekawa and T. Hayashi: Effects of ribonuclease digestion of ribonucleic acid on the hemolysin formation. J. Biochem. (Tokyo) 43, 833 (1956).

    Google Scholar 

  18. Younathan, E. S., and S. S. Barkulis: Effect of some antimetabolites on the production of streptolysin. J. Bact. 74, 151 (1957).

    Google Scholar 

  19. McCarty, M.: Streptococcal infections. Columbia University Press 1954.

  20. Okamoto, H.: A study on the phenomenon of the high promotion by nucleic acid of the production of streptococcal hemolysin, streptolysin S. Symp. Soc. Cell. Chem. 3, 145 (1954).

    Google Scholar 

  21. Bernheimer, A. W.: Properties of certain rapidly acting bacterial toxins as illustrated by streptolysins O and S. Bact. Rev. 12, 195 (1948).

    Google Scholar 

  22. Ito, R., T. Okami and M. Yoshimura: On the production of streptolysin by resting hemolytic streptococci suspended in nucleic acid solution. Jap. med. J. 1, 253 (1948).

    Google Scholar 

  23. Bernheimer, A. W., J. E. Winter, P. J. Ortiz, S. Ochoa, F. Egami, K. Tanaka, T. Hayashi and S. Mii: Induction of streptolysin formation by biosynthetic polyribonucleotides. Biochim. biophys. Acta (1957).

  24. Ito, R.: Über die spezifische entgiftende Wirkung der Farbstoffe der Trypanblaureihe auf das Streptolysin. Folia pharmacol. jap. 30, 20 (1940).

    Google Scholar 

  25. Rosendal, K., and A. W. Bernheimer: Paradoxical effect of congo red on the toxicity of streptolysin S for mice. J. Immunol. 68, 53 (1952).

    Google Scholar 

  26. Miyaji, T.: Studies on the mode of anti-streptolysin S action of trypan blue. Ann. R. Tbc. (Kanazawa) 11 (3), 237 (1953).

    Google Scholar 

  27. Ito, R., T. Okami, M. Yoshimura and S. Sagara: The inhibition of the production of hemolytic toxin of Streptococcus pyogenes by 0,0′-dihydroxyazobenzene and related compounds. Jap. med. J. 1, 260 (1948).

    Google Scholar 

  28. Himeno, Y.: Experiments on the influence of various derivatives in the dihydroxyazobenzene series upon the production of streptolysin S by Streptococcus hemolyticus in the resting cell system. Ann. R. Tbc. (Kanazawa) 12 (2), 111 (1954).

    Google Scholar 

  29. Koshimura, S., R. Shimizu, T. Masusaki, T. Ohta and G. Kishi: On the formation of streptolysin S by acting hemolytic streptococci on tumor cells. Jap. J. Microbiol. 2 No 1 (1958).

    Google Scholar 

  30. Hirata, R.: Experimental anticancer studies. Part I. The preparation of 6-(2′-hydroxy-3′,5′-dibromophenylazo)-4-hexylresorcinol and related compounds, with brief reference to their anticancer activity. Pharm. Bull. (Tôkyô) 4, 60 (1956).

    Google Scholar 

  31. Koshimura, S., K. Murasawa, E. Nakagawa, M. Ueda, Y. Bando and R. Hirata: Experimental anticancer studies. Part II. On the anti-tumor effect of 6-(2′-hydroxy-3′,5′-dihalophenylazo)-4-hexylresorcinol and related compounds on Yoshida sarcoma and Ehrlich ascites carcinoma in vivo. Gann 47, 393 (1956).

    Google Scholar 

  32. Koshimura, S., K. Murasawa, E. Nakagawa, M. Ueda, Y. Bando and R. Hirata: Experimental anticancer studies. Part III. On the influence of living hemolytic streptococci upon the invasion power of Ehrlich ascites carcinoma in mice. Jap. J. exp. Med. 25, 93 (1955).

    Google Scholar 

  33. Koshimura, S., K. Murasawa, M. Ueda, Y. Bando, R. Hirata, T. Ohta and M. Ishikawa: Experimental anticancer studies. Part IV. On the influence of hydroxybenzylidene-, phenoxazone- and quinone-derivatives, and various compounds on Yoshida sarcoma in rat. Gann 47, 391 (1956).

    Google Scholar 

  34. Hirata, R.: Experimental anticancer studies. Part V. Bis(2-hydroxy-3,5-dibromophenylazo)-alkylphloroglucinols and their inhibitory effect against Ehrlich ascites carcinoma in mice. Jap. J. exp. Med. 27, 99 (1957).

    Google Scholar 

  35. Ohta, T.: Experimental anticancer studies. Part VI. Experiments on the influence of living A group hemolytic streptococci and several other species of microorganisms on the invasion power of Ehrlich carcinoma cells to mice. Jap. J. exp. Med. 27, 107 (1957).

    Google Scholar 

  36. Busch, E.: Berl. klin. Wschr. 1866, 245.

  37. Fehleisen: Über die Züchtung der Erysipelkokken auf künstlichem Nährboden und ihre Übertragbarkeit auf den Menschen. Dtsch. med. Wschr. 1882, 553.

  38. Bruns, P.: Die Heilwirkung des Erysipelas auf Geschwülste. Bruns' Beitr. klin. Chir. 3, 443 (1888).

    Google Scholar 

  39. The detailed data will be published in the near future.

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Authors and Affiliations

  1. Research Institute of Tuberculosis, and Department of Pharmacology, School of Medicine, Kanazawa University, Japan

    H. Okamoto, S. Koshimura, R. Hirata, K. Murasawa, Y. Bando & R. Shimizu

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  1. H. Okamoto
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  2. S. Koshimura
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  3. R. Hirata
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  4. K. Murasawa
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  5. Y. Bando
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  6. R. Shimizu
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Okamoto, H., Koshimura, S., Hirata, R. et al. Some data in anti-cancer experiments. Z Krebs-forsch 62, 408–418 (1958). https://doi.org/10.1007/BF00528009

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