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Sensitive flame-photometric-detector analysis of thiodiglycolic acid in urine as a biological monitor of vinyl chloride

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Summary

A simple and selective method to detect thiodiglycolic acid (TdGA) in urine by flame-photometric-detector (FPD) of gas chromatograph (GC) is described. The detection limit of this method is less than 1 ng without disturbances. Urine from 64 subjects exposed to different air concentration of vinyl chloride (VCM) from 0.3 ppm to more than 100 ppm in three groups and 78 subjects was detected in this way. A comparison of the results of these groups shows significant differences between the control and two exposed groups.

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References

  • Draminski W, Trojanowska B (1981) Chromatographic determination of thiodiglycolic acid—a metabolite of vinyl chloride. Arch Toxicol 48:289–292

    Google Scholar 

  • Green T, Hathway DE (1976) The biological fate in rats of vinyl chloride in relation to its oncogenicity. Chem Biol Interact 11:545–562

    Google Scholar 

  • Heger M, Müller G, Norpoth K (1982) Untersuchungen zur zwischen Vinylchlorid-Aufnahme und Metabolitenausscheidung bei 15 VCM-Exponierten. Int Arch Occup Environ Health 50:187–196

    Google Scholar 

  • Müller G, Norpoth K, Eckard R (1976) Identification of two urine metaboilites of vinyl chloride by GC-MS investigations. Int Arch Occup Environ Health 38:69–75

    Google Scholar 

  • Müller G, Norpoth K, Kustees E, Herweg K, Versin E (1978) Determination of thiodiglycolic acid in urine specimens of vinyl chloride exposed workers. Int Arch Occup Envir Health 41:199–205

    Google Scholar 

  • Müller G, Norpoth K, Wickramasinghe RE (1979) An analytical method, using GC-MS, for the quantitative determination of urinary thiodiglycolic acid. Int Arch Occup Environ Health 44:185–191

    Google Scholar 

  • Tarkowski S, Wisniewska-Knzpl JM, Klimczak J, Draminski W, Wroblewska K (1980) Urinary excretion of thiodiglycolic acid and hepatic content of free thiols in rats at different levels of exposure to vinyl chloride. J Hyg Epidemiol Microbiol Immunol 24:253–261

    Google Scholar 

  • Watanabe PG, McGowan GR, Gehring PJ (1976) Fate of 14C vinyl chloride after single oral administration in rats. Toxicol Appl Pharmacol 36:339–352

    Google Scholar 

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Authors and Affiliations

  1. Institute for Industry Hygiene and Occupational Diseases Peking, 100020, Peking, China

    Z. Y. Chen, X. R. Gu & M. Z. Cui

  2. Sanitation and Antiepidemic Station Peking, China

    X. X. Zhu

Authors
  1. Z. Y. Chen
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  2. X. R. Gu
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  3. M. Z. Cui
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  4. X. X. Zhu
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Chen, Z.Y., Gu, X.R., Cui, M.Z. et al. Sensitive flame-photometric-detector analysis of thiodiglycolic acid in urine as a biological monitor of vinyl chloride. Int. Arch Occup Environ Heath 52, 281–284 (1983). https://doi.org/10.1007/BF00526527

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  • DOI: https://doi.org/10.1007/BF00526527

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