Zeitschrift für Krebsforschung

, Volume 65, Issue 3, pp 201–208 | Cite as

Precancerous lesions of endometrium

  • Arthur T. Hertig
  • Hazel Gore


Cystic and adenomatous hyperplasia, anaplasia (dysplasia) and carcinoma in situ of the endometrium have been observed in endometrium prior to the development of adenocarcinoma both in retrospective and prospective studies. The continuous unopposed action of estrogen in the human who harbors granulosatheca cell tumors seems to be related to the production of endometrial hyperplasia and endometrial carcinoma. In premenopausal patients who are still ovulating adenocarcinoma probably arises in an abnormal focus which fails to respond to progesterone or in a focus of atypical hyperplasia resulting from prolonged estrogenic stimulation prior to ovulation.


Public Health Carcinoma Cell Tumor Estrogen Adenocarcinoma 
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Cystische und adenomatöse Hyperplasie, Anaplasie (Dysplasie) und Carcinoma in situ des Endometriums wurden im Endometrium vor der Entwicklung eines Adenocarcinoms sowohl bei retrospektiver wie prospektiver Untersuchung beobachtet. Die dauernde und ungehemmte Wirkung von Oestrogenen bei Menschen mit Granulosazelltumoren scheint in Zusammenhang zu stehen mit der Entstehung von Hyperplasien und Carcinomen des Endometriums. Bei Patienten kurz vor der Menopause, welche noch ovulieren, entsteht das Adenocarcinom wahrscheinlich in einem abnormen Schleimhautbezirk, der nicht auf Progesteron reagiert, oder in einem Herd atypischer Hyperplasie auf Grund des verlängerten oestrogenen Reizes vor der Ovulation.


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Copyright information

© Springer-Verlag 1963

Authors and Affiliations

  • Arthur T. Hertig
    • 1
    • 2
  • Hazel Gore
    • 1
    • 2
  1. 1.Department of PathologyHarvard Medical SchoolBostonUSA
  2. 2.Pathology LaboratoryFree Hospital for WomenBrooklineUSA

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