Zeitschrift für Krebsforschung

, Volume 72, Issue 4, pp 350–355 | Cite as

Uptake of 51Cr-β-glycerophosphate by experimental brain tumor

  • Leopoldo J. Anghileri


A new radioactive compound the 51Cr-β-glycerophosphate complex, which accumulates in different types of tumor, has been assayed in mice transplanted subcutaneously with brain tumor. A very high tumor to brain uptake ratio was observed throughout the experiment (72 h). The optimal interval seemed to be between 6 and 24 h. The biochemical mechanism involved in the accumulation of the compound by the Tumor appeared to be more complex than a simple phosphomonoesterase action.


Public Health Cancer Research Brain Tumor High Tumor Biochemical Mechanism 
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Aufnahme von 51Cr-B-Glycerophosphat von experimentell-induzierten Hirntumoren


Eine neue radioaktive Verbindung, der 51Cr-B-glycerophosphat-Komplex, welches in verschiedenen Typen von Tumoren gespeichert wird, wurde in Mäusen, die subkutane Hirntumoren trugen, biologisch ausgewertet. Während der ganzen Untersuchungszeit von 72 Std speicherte der Tumor, wenn mit Hirn verglichen, viel mehr Radioaktivität auf. Die optimale Zeit war offensichtlich zwischen 6–24 Std. Der biochemische Mechanismus der Verabreichung der Verbindung durch den Tumor erschien komplizierter zu sein als eine einfache Wirkung von Phosphomonoesterase.


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Copyright information

© Springer-Verlag 1969

Authors and Affiliations

  • Leopoldo J. Anghileri
    • 1
    • 2
  1. 1.Johns Hopkins Medical Institutions Department of Radiological Science Baltimore
  2. 2.University of Colorado Medical CenterDenver

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