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Uptake of 3H ascites albumin by Yoshida ascites tumor cells

Aufnahme von 3H Ascites albumin durch Yoshida Ascites Tumorzellen

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Zusammenfassung

Albumin von Yoshida Ascites-Tumor-Flüssigkeit wurde in vivo, durch Injektion 3 H l-Leucine markiert und dann isoliert. Zellen von Yoshida Ascites-Tumor wurden dann in vitro mit diesem radioaktiven Albumin inkubiert, wie das Albumin durch eine mit der Zeit zunehmende Radioaktivität in den Tumorzellen zeigte.

Solche unter verschiedenen experimentellen Bedingungen erzielten Resultate scheinen zu beweisen, daß das 3H-Albumin durch einen aktiven und komplexen Mechanismus aufgenommen wird, in welchem wahrscheinlich auch Pinocytosis eine Rolle spielt.

Summary

Albumin of ascites tumor fluid was labelled in vivo in the ascites bearing rats by injecting tritiated l-Leucine.

Cells of Yoshida ascites tumor were incubated in vitro with this radioactive albumin. Incubations for several periods of time resulted in incorporation of a consistent amount of radioactivity into the tumor-cells.

The results obtained under different experimental conditions seem to indicate that the 3H-albumin is taken up by an active and complex mechanism probably involving pinocytosis.

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References

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Authors and Affiliations

  1. Radiumstationen Aarhus, Cancer Research Institute, Denmark

    Maria L. marcante (Fellow of the „Centro Relazioni Culturali”, Ministero Affari Esteri)

  2. Istituto Regina Elena per lo studio e la cura dei tumori Rome, Italy

    Maria L. marcante (Fellow of the „Centro Relazioni Culturali”, Ministero Affari Esteri)

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  1. Maria L. marcante
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marcante, M.L. Uptake of 3H ascites albumin by Yoshida ascites tumor cells. Z Krebs-forsch 72, 305–311 (1969). https://doi.org/10.1007/BF00525801

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  • DOI: https://doi.org/10.1007/BF00525801

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