Zeitschrift für Krebsforschung

, Volume 60, Issue 5, pp 597–608 | Cite as

Cytological studies of tumors

XV. Reciprocal effects on growth of two different tumors in the same host
  • Sajiro Makino
  • Akira Tonomura


The present paper describes observations concerning the growth of two different rat ascites tumors, MTK-sarcoma II and Takeda sarcoma, implanted in the same host. Two types of tumor cells inoculated in the same host affect each other; the mitotic rate of the tumor cells is strikingly decreased and their damage with consequent retardation of tumor growth is remarkable. Growth of Takeda sarcoma is inhibited by either co-existence or pre-existance of MTK-sarcoma II in the same host. In the pre-existence of Takeda sarcoma, the damage to tumor cells of both tumors and consequent retardation of the tumor growth are very remarkable, prolonging the life of tumor-bearing animals in many cases.


Public Health Tumor Cell Tumor Growth Cancer Research Sarcoma 
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Copyright information

© Springer-Verlag 1955

Authors and Affiliations

  • Sajiro Makino
    • 1
  • Akira Tonomura
    • 1
  1. 1.Zoological InstituteHokkaido UniversitySapporo(Japan)

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