Zeitschrift für Krebsforschung

, Volume 67, Issue 3, pp 233–246 | Cite as

Experimental induction of lymphatic leukosis in rats following ingestion of human neoplasms

  • Yukio Hamazaki


It is assumed that an oncogenic agent can be demonstrated by a route of spontaneous infection in nature, i.e. feeding test. Using this approach, young albino rats which normally show little incidence of spontaneous leukosis have exhibited a much higher incidence of leukosis following ingestion of human neoplasms. This leukosis has been serially transmitted with a cell-free filtrate and nuclear inclusion bodies have been demonstrated in the epithelial cells of the urinary tubules and in the reticulum cells of the lymph nodes and the spleen.


Public Health Lymph Node Epithelial Cell Cancer Research Human Neoplasm 
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Es wird angenommen, daß ein onkogenes Agens auf dem Wege einer natürlichen Infektion, nämlich durch Verfütterung, nachgewiesen werden kann. Bei entsprechenden Versuchen zeigt es sich, daß junge Albino-Ratten, welche sonst sehr selten eine spontane Leukose aufweisen, viel häufiger an dieser erkranken, wenn ihnen menschliche Neoplasmen verfüttert wurden. Die Leukose konnte serienweise mit einem zellfreien Filtrat übertragen werden. Einschlußkörper in den Zellkernen wurden in den Epithelzellen der Harnkanälchen und in den Reticulumzellen der Lymphdrüsen und der Milz nachgewiesen.


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  1. Arnesen, K.: Preleukemic changes in the thymus of mice: A study of the AKR/O strain. Acta path. microbiol. scand. 43, 350–364 (1958).Google Scholar
  2. Cowdry, E. V., A. M. Lucas, and H. Fox: Distribution of nuclear inclusion in wild animals. Amer. J. Path. 11, 237–253 (1935).Google Scholar
  3. Farris, E. J., and E. H. Yeakel: Spontaneous and transplanted reticulum cell sarcomas in Wistar rats. Amer. J. Path. 20, 773–781 (1944).Google Scholar
  4. Goodman, S. B., and M. H. Block: The histogenesis of Gross's viral induced mouse leukemia. Cancer Res. 23, 1634–1640 (1963).Google Scholar
  5. Graetz, Fr.: Über die lymphatische Leukemia mit besonderer Berücksichtigung ihrer großzelligen Form. Beitr. path. Anat. 49, 338–383 (1910).Google Scholar
  6. Gross, L.: “Spontaneous” leukemia developing in C3H mice following inoculation, in infancy, with AK-leukemic extract, or AK-embryos. Proc. Soc. exp. Biol (N.Y.) 76, 27–32 (1951).Google Scholar
  7. Hamazaki, Y.: On the intestinal infection of carcinogenic agents and experimental induction of cancer. Acta Un. it. ct. Cancer. 15, 154–162 (1959).Google Scholar
  8. Hamazaki, Y.: Widespread persistence of filtrable agents in transplantable tumors. Bul. Cancer Inst. Okayama Univ. No. 2, 1–122 (1962).Google Scholar
  9. Hamazaki, Y.: Symposium on carcinogenesis and viruses. 22nd Jap. Cancer Congr. in Okayama, Oct. 1963.Google Scholar
  10. Moore, A. E., and A. C. Caparo: Tumors occuring in newborn mice after inoculation of human cancer material. Cancer Res. 24, 765–769 (1964).Google Scholar
  11. Schridde, H.: Myeloblasten, Lymphoblasten und lymphoblastische Plasmazellen. Beitr. path. Anat. 41, 223–238 (1907).Google Scholar
  12. Shay, H., M. Gruenstein, H. E. Marx, and L. Glazer: The development of lymphatic and myelogenous leukemia in Wistar rats following gastric instillation of methylcholanthrene. Cancer Res. 11, 29–34 (1951).Google Scholar
  13. Stewart, S. E., B. E. Eddy, and N. Borgese: Neoplasms in mice inoculated with a tumor agent carried in tissue culture. J. nat. Cancer Inst. 20, 1223–1243 (1958).Google Scholar

Copyright information

© Springer-Verlag 1965

Authors and Affiliations

  • Yukio Hamazaki
    • 1
  1. 1.Department of PathologyOkayama University Medical SchoolOkayamaJapan

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