Zeitschrift für Krebsforschung

, Volume 67, Issue 3, pp 233–246 | Cite as

Experimental induction of lymphatic leukosis in rats following ingestion of human neoplasms

  • Yukio Hamazaki
Article
  • 17 Downloads

Summary

It is assumed that an oncogenic agent can be demonstrated by a route of spontaneous infection in nature, i.e. feeding test. Using this approach, young albino rats which normally show little incidence of spontaneous leukosis have exhibited a much higher incidence of leukosis following ingestion of human neoplasms. This leukosis has been serially transmitted with a cell-free filtrate and nuclear inclusion bodies have been demonstrated in the epithelial cells of the urinary tubules and in the reticulum cells of the lymph nodes and the spleen.

Keywords

Public Health Lymph Node Epithelial Cell Cancer Research Human Neoplasm 

Zusammenfassung

Es wird angenommen, daß ein onkogenes Agens auf dem Wege einer natürlichen Infektion, nämlich durch Verfütterung, nachgewiesen werden kann. Bei entsprechenden Versuchen zeigt es sich, daß junge Albino-Ratten, welche sonst sehr selten eine spontane Leukose aufweisen, viel häufiger an dieser erkranken, wenn ihnen menschliche Neoplasmen verfüttert wurden. Die Leukose konnte serienweise mit einem zellfreien Filtrat übertragen werden. Einschlußkörper in den Zellkernen wurden in den Epithelzellen der Harnkanälchen und in den Reticulumzellen der Lymphdrüsen und der Milz nachgewiesen.

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Copyright information

© Springer-Verlag 1965

Authors and Affiliations

  • Yukio Hamazaki
    • 1
  1. 1.Department of PathologyOkayama University Medical SchoolOkayamaJapan

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