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The histological and autoradiographical studies of mouse liver during the course of carcinogenesis by dimethylnitrosamine

Histologische und autoradiographische Untersuchungen der Mäuseleber während des Ablaufs der Cancerogenese durch Dimethylnitrosamin

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Zusammenfassung

Zwischen der Proliferation der Sinusendothelien und der autoradiographischen Lokalisation von H3-Thymidin wurde eine ausgesprochene Beziehung festgestellt. Dieser Befund weist darauf hin, daß das durch Dimethylnitrosamin erzeugte maligne Hämangioendotheliom der Mäuseleber mit einer Proliferation der Sinusendothelien beginnen dürfte.

Summary

A definite correlation was observed between the proliferation of sinusoidal endothelial cells and the autoradiographic localization of H3-thymidine in the liver. These findings indicated that malignant hemangioendothelial sarcoma of mouse liver induced with DMN might develop from the proliferation of sinusoidal endothelial cells.

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Authors and Affiliations

  1. Department of Experimental Pathology, Cancer Institute, Tokyo

    Shozo Takayama

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  1. Shozo Takayama
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Additional information

This work was supported by a Grant-in-Aid for Scientific Research from the Ministry of Education, Japan.

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Takayama, S. The histological and autoradiographical studies of mouse liver during the course of carcinogenesis by dimethylnitrosamine. Z Krebs-forsch 71, 246–254 (1968). https://doi.org/10.1007/BF00524752

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  • DOI: https://doi.org/10.1007/BF00524752

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