Summary
A study was made of the behaviour of certain selected non-ionic surface active agents (sorbitan fatty acid esters, and polyoxyethylene sorbitan fatty acid esters) — both those found to be highly potent tumour promoters, and those which were ineffective — towards skin collagen of the rabbit. Collagen obtained from rat tail tendons served as further comparison.
First some motivations are given about the reasons why the present investigation was carried out.
The composition of the amino acids of the presipitated collagen was analyzed paperchromatographically. The molecular structure of the collagen was studied with wide-angle X-ray diffraction technique as well as infra-red spectrographically. The appearance of the corresponding cutaneous structures was examined histologically.
It was demonstrated that no compounds tested (not even the most potent tumour promoter) produced any detectable alterations in the skin collagen of the rabbit.
The results are discussed with special emphasis on the observation that the new type tumour promoters exert the effect by way of their molecular orientation rather than by chemical means.
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Diese Untersuchung wurde teilweise unterstützt durch Zuschüsse von folgenden Institutionen und Fonds: Aus den Vereinigten Staaten von Amerika National Institutes of Health, Public Health Service, Forschungsstipendium C-2930 M & G, erteilt nach Empfehlung des National Advisory Cancer Council, und Damon Runyon Memorial Fund for Cancer Research, Inc., Forschungsstipendium DRG-292; aus Finnland Pehr Oscar Klingendahl Foundation, Sigrid Juselius' stiftelse, Unterrichtsministerium des finnischen Staates und Staatliche naturwissenschaftliche Kommission.
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Setälä, K., Holsti, P., Lundbom, S. et al. Untersuchungen über das Verhalten einiger nichtionisierbaren oberflächenaktiven Tumorauslösersubstanzen zum Kollagen des Dermas beim Kaninchen. Z Krebs-forsch 61, 569–577 (1957). https://doi.org/10.1007/BF00524632
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DOI: https://doi.org/10.1007/BF00524632