Abstract
Ia specificity 22 is expressed on a hybrid I-E molecule formed by the association of a beta chain (Ae) coded for by the I-A subregion and an alpha chain (Eα) encoded by the I-E subregion. Ia.22 can be generated by the complementation of A b, A k A s, A r with E d, E k, E vp, E r, E w3, Eu, E v but not E b, E f, E q, and E s. With the exception of H-2 p which does not complement with A s to generate Ia.22, all Ia.7-positive (I-E) haplotypes can provide the permissive E α allele. It is postulated that Ia.22 is a combinatorial Ia determinant generated by the association of the alpha and beta chains. These determinants are probably involved in the immune recognition of antigens under dual Ir-gene control.
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Lafuse, W.P., McCormick, J.F., Corser, P.S. et al. Hybrid (combinatorial) Ia specificities: Gene complementations to generate Ia.22. Immunogenetics 13, 115–125 (1981). https://doi.org/10.1007/BF00524609
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DOI: https://doi.org/10.1007/BF00524609