Skip to main content
SpringerLink
Log in

Cross-reactivity between RSV-induced tumor antigen and B5 MHC alloantigen in the chicken

  • Original Investigations
  • Published:
Immunogenetics Aims and scope Submit manuscript

Abstract

Lymphocytes from chickens homozygous (B 2 B 2) at the major histocompatibility complex (MHC) were tested for cytotoxic activity against five types of target chicken embryo fibroblasts (CEF). Lymphocytes from B2B2 chickens bearing RSV-induced tumors lysed in vitro targets of B 2 B 2 and B 5 B 5 RSV-infected CEF and B 5 B 5 normal CEF, but did not lyse B 2 B 2 and B 24 B 24 normal CEF. Lymphocytes from normal B 2 B 2 chickens did not lyse any of the five types of CEF targets. Alloantisera absorption studies showed that both RSV-infected and uninfected CEF shared alloantigens, in particular B-F alloantigens, with syngeneic erythrocytes. Absorption with B 2 B 2 RSV-infected CEF significantly lowered the titer of B 2 B 2 anti-B 5 B 5 alloantisera. Cross-reactivity between B 5 antigen(s) and tumor-associated antigen was suggested and the nature of the cross-reactivity was discussed. It is hypothesized that this cross-reactivity prevents B 5 B 5 chickens from recognizing RSV-induced tumors as foreign, enhances tumor growth and leads to death of the host.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  • Archambault, L. P., Dunlop, W. R., Cucchiara, F. P., Collins, W. M., and Corbett, A. C.: A simplified technique for obtaining purified peripheral lymphocytes from chickens. Poultry Sci. 55: 1972–1973, 1976

    Google Scholar 

  • Bevan, M. J.: Killer cells reactive to altered-self antigens can also be alloreactive. Proc. Natl. Acad. Sci. U.S.A. 74: 2094–2098, 1977

    Google Scholar 

  • Carbone, G., Inverizzi, G., Meschini, A., and Parmiani, G.: In vitro and in vivo expression of original and foreign H-2 antigens and of the tumor-associated transplantation of a murine fibrosarcoma. Int. J. Cancer 21: 85–93, 1978

    Google Scholar 

  • Collins, W. M., Briles, W. E., Zsigray, R. M., Dunlop, W. R., Corbett, A. C., Clark, K. K., Marks, J. L., and McGrail, T. P.: The B locus (MHC) in the chicken: Association with the fate of RSV-induced tumors. Immunogenetics 5: 333–343, 1977

    Google Scholar 

  • Dixon, D. O. and Duncan, D. B.: Minimum Bayes risk t-intervals for multiple comparisons. J. Am. Stat. Assoc. 70: 822–831, 1975

    Google Scholar 

  • Finberg, R., Burakoff, S., Cantor, H., and Benacerraf, B.: Biological significance of alloreactivity: T cells stimulated by Sendai virus-coated syngeneic spleen cells specifically lyse allogeneic target cells. Proc. Natl. Acad. Sci. U.S.A. 75: 5145–5149, 1978

    Google Scholar 

  • Fyfe, D., Ponzio, N. M., and Finke, J.: Presence of foreign H-2 like antigenic specificities on reticulum cell sarcoma cells syngeneic to SJL mice. Proc. Am. Assoc. Cancer Res. 19: 154, 1978

    Google Scholar 

  • Garrido, F., Festenstein, H., and Schirrmacher, V.: Further evidence for derepression of H-2 and Ig like specificities of foreign haplotypes in mouse tumor cell lines. Nature 261: 704–706, 1976

    Google Scholar 

  • Garrido, F., Schirrmacher, V., and Festenstein, H.: Studies on H-2 specificities on mouse tumor cells by a new microradio assay. J. Immunogenet. 4: 15–27, 1977

    Google Scholar 

  • Hála, K., Vilhelmová, M., and Hartmanová, J.: The structure of the major histocompatibility complex of the chicken. In A. A. Benedict (ed.): Avian Immunology Advances in Experimental Medicine and Biology, vol. 88, pp. 227–232, 1977

  • Hale, A. H.: The spatial relationship of the viral and H-2 antigens recognized by anti-viral CTLs. Immunogenetics 10: 469–479, 1980

    Google Scholar 

  • Hall, M. R., Qualtiere, L. F., and Meyers, P.: Cellular and humoral immune reactivity to tumor associated antigens in chickens infected with Rous sarcoma virus. J. Immunology 123: 1097–1105, 1979

    Google Scholar 

  • Hanafusa, H.: Rapid transformation of cells by Rous sarcoma virus. Proc. Natl. Acad. Sci. U.S.A. 63: 318–325, 1969

    Google Scholar 

  • Heinzelmann, E. W., Zsigray, R. M., and Collins, W. M.: Increased growth of RSV-induced tumors in chickens partially tolerant to MHC alloamigens. Immunogenetics 12: 275–284, 1981

    Google Scholar 

  • Invernizzi, G. and Parmiani, G.: Tumor associated transplantation antigens of chemically induced sarcomata cross-reacting with allogeneic histocompatibility antigens. Nature 254: 713–714, 1975

    Google Scholar 

  • Invernizzi, G., Carbone, G., and Parmiani, G.: Alien histocompatibility determinants on the cell surface of sarcomas induced by methycholanthrene. II. In vitro serological studies. Tumor 63: 181–194, 1977 a

    Google Scholar 

  • Invernizzi, G., Carbone, G., Meschini, A., and Parmiani, G.: Multiple foreign non-H-2 determinants on the surface of a chemically-induced murine sarcoma. J. Immunogenet. 4: 97–106, 1977b

    Google Scholar 

  • Israel, E. and Wainberg, M. A.: Development of cellular anti-tumor immunity in chickens bearing tumors induced by Rous sarcoma virus. J. Immunology 118: 2237–2242, 1977

    Google Scholar 

  • Iványi, P., van Mourik, P., Breuning, M., and Melief, C. J. M.: Anti-H-2 antibodies induced by syngeneic immunization. Immunogenetics 10: 319–332, 1980

    Google Scholar 

  • Lutz, W.: Statistical methods as applied to immunological data. In D. M. Weit (ed.): Handbook of Experimental Immunology., 3rd ed., pp. A2.1-A2.29, Blackwell Scientific Publications, Oxford, London, Edinburgh, Melbourne, 1978

    Google Scholar 

  • Martin, W. J., Gipson, T. G., and Rice, J. M.: H-2a associated alloantigen expressed by several transplancentally induced lung tumors of C3Hf mice. Nature 265: 738–739, 1977

    Google Scholar 

  • McGrail, T. P., Collins, W. M., and Dunlop, W. R.: Lymph ototoxicity of chickens bearing Rous sarcomas. Poultry Sci. 57: 90–94, 1978

    Google Scholar 

  • Meschini, A., Invernizzi, G. M., and Parmiani, G.: Expression of alien H-2 specificities on a chemically induced BALB/c fibrosarcoma. Int. J. Cancer 20: 271–283, 1977

    Google Scholar 

  • Meschini, A. and Parmiani, G.: Anti-H-2 alloantibodies elicited by syngeneic immunizations with a chemically induced fibrosarcoma. Immunogenetics 6: 117–123, 1978

    Google Scholar 

  • More, R., Yron, I., Sasson, S. B., and Weiss, D. W.: In vitro studies on cell-mediated cytotoxicity by means of a terminal labeling technique. Cell. Immunol. 15: 382–391, 1975

    Google Scholar 

  • Nathenson, S. G., Brown, J. L., Ewenstein, B. M., Nisizawa, T., Sears, D. W., and Freed, J. H.: Structural differences between parent and variant H-2K glycoproteins from mouse strains carrying H-2 gene mutations. Cold Spring Harbor Symp. Quant. Biol. 41: 343–349, 1977

    Google Scholar 

  • Parmiani, G. and Invernizzi, G.: Alien histocompatibility determinants on the cell surface of sarcomas induced by methylcholanthrene. I. In vivo studies Int. J. Cancer 16: 756–767, 1975

    Google Scholar 

  • Parmiani, G., Carbone, G., Invernizzi, G., Pierotti, M. A., Sensi, M. L., Rogers, M. J., and Appella, E.: Alien histocompatibility antigens on tumor cells. Immunogenetics 9: 1–24, 1979

    Google Scholar 

  • Pellegrino, M. A., Ferrone, S., and Hayflick, L.: Changes in Hl-A antigens profiles on SV40-transformed human fibroblasts. Exp. Cell Res. 97: 340–345, 1976

    Google Scholar 

  • Perry, L. L. and Green, M. I.: The relationship between tumor antigens and alloantigens: Crossreactivity due to differential context of T cell antigen recognition. J. Immunmol., in press, 1980

  • Pfizenmaier, K., Jung, H., Kurrle, R., Röllinghoff, M., and Wagner, H.: Anti-H-2Dd alloreactivity mediated by Herpes-Simplex-virus specific cytotoxic H-2k T lymphocytes is associated with H-2Dk. Immunogenetics 10: 395–404, 1980

    Google Scholar 

  • Prat, M., Rogers, M. J., and Appella, E.: Alloantisera reacting with tumor cells of inappropriate haplotype. I. Characterization of target antigens. J. Natl. Cancer Inst. 61: 527–534, 1978

    Google Scholar 

  • Robinson, P. J. and Schirrmacher, V.: Differences in the expression of histocompatibility antigens on mouse lymphocytes and tumor cells: Immunochemical studies. Ear. J. Immunol. 9: 61–66, 1979

    Google Scholar 

  • Roman, J. M. and Bonavida, B.: Expression of inappropriate H-2 antigens on SJL reticulum cell tumors. Transplant Proc. 11: 1365–1366, 1979

    Google Scholar 

  • Russell, J. H., Ginns, L. C., Terres, G. and Eisen, H. N.: Tumor antigens as inappropriately expressed normal alloantigens. J. Immunol. 122: 912–919, 1979

    Google Scholar 

  • Schierman, L. W., Watanabe, D. H., and McBride, R. A.: Genetic control of Rous sarcoma regression in chickens: Linkage with the major histocompatibility complex. Immunogenetics 5: 325–332, 1977

    Google Scholar 

  • Snedecor, G. W. and Cochran, W. G.: Statistical Methods, 6th ed. Iowa State University Press, Ames, 1967

    Google Scholar 

  • Sommes, R. G.: Registry of poultry genetic stocks in North America. Conn. (Storrs) Agr. Exp. Sta. Bul. 473: 1–46, 1975

    Google Scholar 

  • Stone, H. A.: Use of highly inbred chickens in research. U.S. Dept. Agr. Res. Set., Tech Bul. 1514: 1–22, 1975

    Google Scholar 

  • von Boehmer, H., Hengartner, H., Nabholz, M., Lenhardt, W., Schreier, M. H., and Haas, W.: Fine specificity of a continuously growing killer cell clone specific for H-Y antigen. Ear. J. Immunol. 9: 592–597, 1979

    Google Scholar 

  • Wainberg, M. A. and Phillips, E. R., Immunity against avian sarcomas. Isr. J. Med. Sci. 12: 388–406, 1976

    Google Scholar 

  • Ziegler, A. and Pink, J. R.C.: Structural similarity of major histocompatibility antigens on leukocytes and erythrocytes. Immunochemistry 15: 515–516, 1978

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Animal Sciences, University of New Hampshire, 03824, Durham, New Hampshire

    Eric W. Heinzelmann & W. M. Collins

  2. Department of Microbiology, University of New Hampshire, 03824, Durham, New Hampshire

    R. M. Zsigray

Authors
  1. Eric W. Heinzelmann
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. R. M. Zsigray
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. W. M. Collins
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Heinzelmann, E.W., Zsigray, R.M. & Collins, W.M. Cross-reactivity between RSV-induced tumor antigen and B5 MHC alloantigen in the chicken. Immunogenetics 13, 29–37 (1981). https://doi.org/10.1007/BF00524603

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00524603

Keywords

Search

Navigation