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Zeitschrift für Krebsforschung

, Volume 62, Issue 2, pp 116–124 | Cite as

The metabolism of neoplastic tissues: The metabolic activity of normal and cancerous rat livers studied with acetate-1-14C in vitro

  • P. Emmelot
  • G. H. van Vals
Article
  • 10 Downloads

Summary

In vitro studies with surviving tissue slices show that neither the activation nor the utilization of acetate-1-14C in four important metabolic sequences is impaired in the neoplastic rat liver following the feeding of p-dimethylaminoazobenzene. Incorporation of 14C from acetate-1-14C into the proteins is very markedly enhanced in the hepatoma and hepatoma-bearing liver as compared with that in the normal and precancerous liver. It is concluded that the citric acid cycle is markedly active in the neoplastic rat liver.

Keywords

Public Health Cancer Research Citric Acid Metabolic Activity Vitro Study 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag 1957

Authors and Affiliations

  • P. Emmelot
    • 1
  • G. H. van Vals
    • 1
  1. 1.Department of BiochemistryAnroni van Leeuwenhoek-Huis: The Netherlands Cancer InstituteAmsterdamthe Netherlands

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