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Prüfung von N-oxyd-Lost auf cancerogene Wirkung an Ratten

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Summary

36 rats were chronicly treated with nitrogen mustard N-oxide. The total dose was 1,3 g/kg body weight. The nitrogen mustard N-oxide was given intravenously, intraperitoneally, orally, and subcutaneously. The middle surviving time of the experimental animals was 714 days that of the control group 750 days. 3 of 14 rats living longer than 735 days had malignant tumours. Therefore in the rat the nitrogen mustard N-oxide must be regarded as a carcinogen but of only little activity. The carcinogenic total dose is nearly 200 times as high as the therapeutic one.

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Authors and Affiliations

  1. Laboratorium der Chirurgischen Universitätsklinik in Freiburg i. Br., Freiburg i. Br., Deutschland

    Dieter Steinhoff & Bok Tschin Kuk

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  1. Dieter Steinhoff
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  2. Bok Tschin Kuk
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Die Arbeit wurde durch die “Deutsche Forschungsgemeinschaft” ermöglicht.

Aus Korea, Stipendiatin des “Deutschen Akademischen Austauschdienstes”

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Steinhoff, D., Kuk, B.T. Prüfung von N-oxyd-Lost auf cancerogene Wirkung an Ratten. Z Krebs-forsch 62, 112–115 (1957). https://doi.org/10.1007/BF00524537

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  • DOI: https://doi.org/10.1007/BF00524537

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