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Untersuchungen über experimentelle Leukämien (VII)

Adenocarcinome, Sarkome und Leukämien bei Mäusen nach subcutanen Injektionen von 3-Hydroxykynurenin

Investigations of experimental leukemia (VII)

Adenomata, sarcomata and leukemia in mice after subcutaneous injections of 3-hydroxy-kynurenine

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Summary

With subcutaneous injections of up to 175 mg of 3-Hydroxy-kynurenine into each 20 g mouse, 32 mice of 140 showed malignant tumors: 8 maeloid leukemias, 10 sarcomas and 11 carcinomas of pancreas and thyroid, two mammary carcinomas and one carcinoma of the urinary bladder.

Zusammenfassung

Mit subcutanen Injektionen von 3-Hydroxy-kynurenin bis zu 175 mg je 20 g Maus konnten bei 140 Tieren 32 bösartige Tumore induziert werden: 8 myeloische Leukämien, 10 Sarkome, 11 kleinalveoläre Adenocarcinome, 2 Mammacarcinome und I Harnblasencarcinom.

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Authors and Affiliations

  1. I. Medizinische Klinik der Universität München, München, Deutschland

    H. Ehrhart, W. Ried, W. Benoit & H. Dörfler

  2. Institut für organische Chemie der Universität Frankfurt a. M, Frankfurt a. M., Deutschland

    H. Ehrhart, W. Ried, W. Benoit & H. Dörfler

Authors
  1. H. Ehrhart
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  2. W. Ried
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  3. W. Benoit
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  4. H. Dörfler
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Additional information

Herrn Prof. Dr. Dr. h.c. mult. A. Butenandt zum 65. Geburtstag freundlichst zugeeignet.

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Ehrhart, H., Ried, W., Benoit, W. et al. Untersuchungen über experimentelle Leukämien (VII). Z Krebs-forsch 71, 1–6 (1968). https://doi.org/10.1007/BF00524495

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