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Einschlüsse von Granulocyten in Krebszellen

Penetration of cancer cells by granulocytes

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Summary

Excessive intracytoplasmic inclusions of neutrophilic polymorphonuclear leukocytes were found in metastatic cancer cells of a hypernephroid renal carcinoma. The reaction for the ASD-chloro-acetate-Esterase is very helpful in identifying the incorporated leukocytes even after disintegration. — The phenomenon observed is due most probably to combined processus of active penetration of cancer cells by granulocytes (emperipolesis) on the one hand and cancer cell phagocytosis of granulocytes on the other. It seems to reflect the interaction of agression and defense mechanisms of blood and cancer cells.

Zusammenfassung

In Lungen- und Lymphknotenabsiedlungen eines hypernephroiden Carcinoms bei einem 42jährigen Mann fanden sich in großer Zahl monströse Carcinomzellen, die in ihrem Cytoplasma vor allem neutrophile Granulocyten in allen Stufen des Abbaus, seltener auch Tumorzellen, einschlossen. Es wird ein aktives Eindringen der Granulocyten in die Tumorzellen (im Sinne einer Granulocyten-Emperipolesis), wahrscheinlich zusammen mit aktiv phagocytärer Leistung der Tumorzellen angenommen. die Beobachtung wird in den Rahmen von wechselseitigen Aggressions- und Abwehrvorgängen von Zellen des leukocytären Systems des Organismus und von Tumorzellen gestellt.

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Authors and Affiliations

  1. Abteilung für Kinderpathologie am Pathologischen Institut der Universität Bonn, Bonn, Deutschland

    W. P. Kunze & A. Gropp

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  1. W. P. Kunze
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  2. A. Gropp
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Kunze, W.P., Gropp, A. Einschlüsse von Granulocyten in Krebszellen. Z Krebs-forsch 73, 218–222 (1970). https://doi.org/10.1007/BF00524401

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  • DOI: https://doi.org/10.1007/BF00524401

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