Zeitschrift für Krebsforschung

, Volume 61, Issue 6, pp 632–648 | Cite as

Histochemische Untersuchungen bei Pagetscher Erkrankung der Vulva

  • Günter Strauss
Article

Summary

One case of Paget's disease of the vulva is described, the 5th case (3rd publication) in literature, which is analysed histochemically. A carcinoma of the cutis was not found.

Besides of the typical Paget-cells, which are considered to be changed regressively, is another anaplastical type of cells, being found in clusters and as single cells.

Both types of cells contain glycogen and a mucopolysaccharid or mucoproteid, which is neutral in typical cells, while being slightly acid in anaplastic ones. Regarding their contents of these carbohydrates, these cells clearly show some differences as to quantity, but not as to essential qualities. It is supposed therefore, that there are no fundamentally different cells, but different functional conditions of the Paget-cells.

The importance of the dendrit-cells for the appearance of melanine in the clusters of Paget-cells is shown, thereby the changes in the epidermis, which were observed, are differentiated as Paget's disease from the intraepidermal melanocarcinoma, in spite of their containing melanine.

Fundamentally we see in mammary as well as in extramammary Paget's disease an epidermotropic praecancerosis of the ducts of the glands (of mamma and sweat glands), which can show histological and clinical differences regarding the development of carcinoma, on account of different anatomical and functional conditions of the respective localisation.

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Literatur

  1. Allen, A. C., and S. Spitz: Malignant melanoma: A clinicopathological analysis of the criteria for diagnosis and prognosis. Cancer (N.Y.) 6, 1 (1953).Google Scholar
  2. Arnd, W.: Über die Pagetsche Erkrankung der Brustwarze. Virchows Arch. 261, 700 (1926).Google Scholar
  3. Arzt, L., u. O. Kren: Die Paget disease mit besonderer Berücksichtigung ihrer Pathogenese. Arch., f. Dermat. 148, 284 (1925).Google Scholar
  4. Braun-Falco, O.: Histochemische und morphologische Studien an normaler und pathologisch veränderter Haut. Arch. f. Dermat. 198, 111 (1954).Google Scholar
  5. Chèvrement, M., et J. Frédéric: Une nouvelle methode histochimique de mise en évidence des substances a fonction sulfhydrile. Archives de Biol. 54, 589 (1943).Google Scholar
  6. Danielli, J. F.: A study of techniques for the cytochemical demonstration of nucleic acids and some components of protein. Symposia. Soc. Exper. Biol. 1, 101 (1947).Google Scholar
  7. Duhring, L.: Deux cas de maladie de Paget du mamelon. Amer. J. Med. Sci. 1883, 116. Ref. Arch. f. Dermat. 16, 139 (1884).Google Scholar
  8. Ewing, J.: Neoplastic diseases, S. 898. Philadelphia u. London: W. B., Saunders Company 1940.Google Scholar
  9. Gössner, W.: Die Perchlorsäure und ihre Anwendung zum histochemischen Nucleinsäurenachweis. Z. wiss. Mikrosk. 61, 377 (1954).Google Scholar
  10. Gomori, G.: Aldehyde-fuchsin: a new stain for elastic tissue. Amer. J. Clin. Path. 20, 665 (1950).Google Scholar
  11. Hale, C. W.: Histochemical demonstration of acid polysaccharids in animal tissue. Nature (Lond.) 157, 802 (1946).Google Scholar
  12. Halmi, N. S.: Differentation of two types of basophils in the adenohypophysis of the rat and mouse. Stain Technol. 27, 61 (1952).Google Scholar
  13. Hamperl, H.: Was sind argentaffine Zellen? Virchows Arch. 286, 811 (1932).Google Scholar
  14. Hartzell, M. B.: Extramammary Paget's disease with a report of a case occuring in the forearm. J. Cutan. Dis. 24, 289 (1906).Google Scholar
  15. Huber, C. P., S. H. Gardiner and A. Michael: Paget's disease of the vulva. Amer. J. Obstetr. 62, 778 (1951).Google Scholar
  16. Inglis, K.: Pagets disease of the nipple with special reference to the changes in the ducts. Amer. J. Path. 22, 1 (1946).Google Scholar
  17. Jacobaeus, H. C.: Paget's disease und sein Verhältnis zum Milchdrüsencarcinom. Virchows Arch. 178, 124 (1904).Google Scholar
  18. Jeffcoate, T. N. A., F. B. Davie and C. V. Harrison: Intraepidermal carcinoma (Bowens disease) of the vulva. A report of two cases. J. Obstetr. 51, 377 (1944).Google Scholar
  19. Kramer, H., and G. M. Windrum: The metachromatic staining reaction. J. Histochem. a. Cytochem. 3, 227 (1955).Google Scholar
  20. Kreibich, C.: Zum Wesen der Pagetschen Krankheit. Berlin. klin. Wschr. 1911, 2193.Google Scholar
  21. Lennox, B., and A. G. E. Pearse: Histochemical characterization of the specific cells in Paget's disease. J. Obstetr. 61, 758 (1954).Google Scholar
  22. Lennox, B., A. G. E. Pearse and W. St. C. Symmers: The frequency and significance of mucin in sweat gland tumors. Brit. J. Canc. 6, 363 (1952).Google Scholar
  23. Lillie, R. D.: Ethylenic reaction of ceroid with performic acid and Schiff reagent. Stain Technol. 27, 37 (1952).Google Scholar
  24. Lillie, R. D., u. H. J. Burtner: Zit. nach. P. Gedigk. Zur Histochemie des Zentralapparates der Zelle. Virchows Arch. 325, 366 (1954).Google Scholar
  25. Lillie, R. D., and J. Greco: Malt diastase and ptyalin in place of saliva in the identification of glycogen. Stain Technol. 22, 67 (1947).Google Scholar
  26. Lison, L.: Histochimie et Cytochimie animales. Paris: Gauthier Villars 1953.Google Scholar
  27. Lübschitz, K.: Paget's disease of the nipple with special reference to its course and treatment. Acta radiol. (Stockh.) 25, 127 (1944).Google Scholar
  28. McManus, J. F. A., and J. E. Cason: Carbohydrate histochemistry studied by acetylation techniques. J. of Exper. Med. 91, 651 (1950).Google Scholar
  29. Muir, R.: Further observations on Paget's disease of the nipple. J. of Path. 49, 299 (1939).Google Scholar
  30. Müller, G.: Über eine Vereinfachung der Reaktion nach Hale (1946). Acta histochemica 2, 68 (1955).Google Scholar
  31. Ogier, E.: Contributo allo studio della malattia di Paget della Vulva. Riv. Ostetr. 10, 530 (1955).Google Scholar
  32. Paget, G. E., H. A. Rowley and A. S. Woodcock: Paget's disease of the vulva: Report of a case. J. of Path. 67, 256 (1954).Google Scholar
  33. Paget, J.: On disease of the mammary areola preceding cancer of the mammary gland. St. Batholomew Hosp. Rep. 10, 87 (1874).Google Scholar
  34. Pearse, A. G. E.: (1) The histochemical demonstration of keratin by methods involving selective oxydation. Quart. J. Microsc. Sci. 92, 393 (1951).Google Scholar
  35. —: (2) Histochemistry Theoretical and Applied. London: J. A. Churchill 1952.Google Scholar
  36. Pischinger, A.: Die Lage des isoelektrischen Punktes histologischer Elemente als Ursache ihrer verschiedenen Färbbarkeit. Z. Zellforsch. 3, 169 (1926).Google Scholar
  37. Ribbert, H.: Über den Paget-Krebs. Med. Wschr. 1905, 1218.Google Scholar
  38. Richter, W.: Beitrage zur normalen und pathologischen Anatomie der apokrinen Hautdrüsen des Menschen mit besonderer Berücksichtigung des Achselhöhlenorgans. Virchows Arch. 287, 277 (1932).Google Scholar
  39. Sandritter, W.: Zit. nach P. Gedigk:Zur Histochemie des Zentralapparates der Zelle. Virchows Arch. 325, 366 (1954).Google Scholar
  40. Schultz-Brauns, O.: Die Geschwülste der Brustdrüse. In Henke-Lubarsch' Handbuch der pathologischen Anatomie, Bd. VII/2, S. 322. Berlin: Springer 1933.Google Scholar
  41. Scott, H. R., and B. P. Clayton: A comparison of the staining affinities of aldehyde-fuchsin and the Schiff-reagent. J. Histochem. a. Cytochem. 1, 366 (1953).Google Scholar
  42. Thin, G.: Malignant papillary dermatitis of the nipple and the breast tumours with which it is found associated. Brit. Med. J. 1881, 760, 798.Google Scholar
  43. Weiner, H. A.: Paget's disease of the skin and its relation to carcinoma of the apokrine sweat glands. Amer. J. Canc. 31, 373 (1937).Google Scholar
  44. Wickham, L.: Maladie de peau dite maladie de Paget. Arch. Med. exper. Anat. path. 2, 46 (1890).Google Scholar

Copyright information

© Springer-Verlag 1957

Authors and Affiliations

  • Günter Strauss
    • 1
    • 2
  1. 1.Universitäts-Frauenklinik MainzMainzDeutschland
  2. 2.Pathologischen Institut der Universität BonnBonnDeutschland

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