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Beiträge zum Wirkungsmechanismus des Degranols

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Zusammenfassung

Mit der von O. Klatt weiterentwickelten Epsteinschen Methode wurde der Abbau in vitro von alkylierenden Mitteln untersucht und mit jenem des Degranols verglichen. Je nach Abbaugeschwindigkeit können drei Typen von Stickstofflostderivaten unterschieden werden. Dabei verhielt sich das Blut von Tumorkranken wie das gesunder Personen. Ein Unterschied zwischen dem Abbau in vivo und dem in vitro war nicht festzustellen. Das Enzymsystem des Blutes düfrte seine Wirkung in Gegenwart der Erythrocyten mit Hilfe der Eiweißkörper entfalten.

Summary

The in vitro degradation of alkylating agents was studied with the O. Klatt modification of the Epstein method, and compared with the degradation of degranol. Three types of nitrogen mustard derivatives could be differentiated according to the speed of breakdown. The blood of cancerous patients reacted like that of healthy persons. A difference between the degradation in vivo and that in vitro was not detectable. The enzyme system of the blood may well exert its effect with erythrocytes present and with the aid of proteins.

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Literatur

  • Bolt, W., F. Ritzl u. H. Nahrmann: Untersuchungen mit einem tritium-markierten N-Lost Derivat in der Karzinombehandlung. Nucl. Med. (Stuttg.) 2 251 (1962).

    Google Scholar 

  • ———: Untersuchungen über Abbau, Verteilung und Ausscheidung von tritium-markiertem Cyclophosphamid im menschlichen Organismus. Klin. Wschr. 40, 834 (1962).

    Google Scholar 

  • Epstein, J., R. W. Rosenthan, and R.J. Ess: Use of γ-4-Nitrobenzyl-pyridine as analytical reagent for ethylimines and alkylating agents. Annal. Chem. 27, 1435 (1955).

    Google Scholar 

  • Klatt, O., A. C. Griffin, and J. S. Stehlin: Method for determinations of phenyl-alanine mustard and related alkylating agents in blood. Proc. Soc. exp. Biol. (N.Y.) 104, 629 (1960).

    Google Scholar 

  • Körös, Z.: Synt. of purine mustard. (Im Druck).

  • Nadkarni, M. V., E. G. Trams, and P. K. Smith: Excretion and distribution studies with radio isotop labelled alkylating droogs in cancer patients. Cancer 14, 953 (1961).

    Google Scholar 

  • Selley, C., and S. Eckhardt: Clinical observations with 1,6-bis-chlorethylamino-1,6-desoxy-D-mannitol-dihydrochloride. Ann. N. Y. Acad. Sci. 68, 1165 (1958).

    Google Scholar 

  • ——: Results after 5 years of tumors and leucaemias with Degranol. Brit. J. clin. Pract. 15, 10 (1961).

    Google Scholar 

  • Varga, L., L. Toldy, Ö. Fehér, and S. Lendvay: Synthesis of new sugar derivatives of potential antitumor activity. J. chem. Soc. 805, (1957).

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Authors and Affiliations

  1. Onkologischen Landesinstitut (Klinisches Laboratorium), Budapest

    Z. Kőrös, F. Hartai, U. Máté-Wójcinska & C. Sellei

  2. technologischen Laboratorium der Fabrik chemisch-pharmazeutischer Produkte, Chinoin, Budapest

    Z. Kőrös, F. Hartai, U. Máté-Wójcinska & C. Sellei

Authors
  1. Z. Kőrös
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  2. F. Hartai
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  3. U. Máté-Wójcinska
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  4. C. Sellei
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Kőrös, Z., Hartai, F., Máté-Wójcinska, U. et al. Beiträge zum Wirkungsmechanismus des Degranols. Z Krebs-forsch 66, 374–378 (1964). https://doi.org/10.1007/BF00524167

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  • DOI: https://doi.org/10.1007/BF00524167

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