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Experimentelle Untersuchungen zur Syncarcinogenese

II. Mitteilung Versuche zur Krebserzeugung bei Mäusen bei gleichzeitiger Applikation von Urethan und 9,10-Dimethyl-1,2-benzanthracen

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Zusammenfassung

Hauttropfungen bei C 57 black-Mäusen mit Urethan (Einzeldosis: 11,2 mg; Gesamtdosis: 1560 mg/Tier) führten vorwiegend (84%) zu “Blutcysten” in der Leber und bei einem tier (2%) zu einem Plattenepithelcarcinom lokal an der Applikationsstelle.

Hauttropfungen mit 9,10-Dimethyl-1,2-benzanthracen (Einzeldosis: 0,0018 mg; Gesamtdosis: 0,0504 mg/Tier) ergaben in 9,5% der Fälle lokale Hautcarcinome.

Wurden beide Substanzen in der gleichen Dosierung kombiniert auf die Haut aufgebracht, dann erhöhte sich die Tumorausbeute nicht. Es liegt also keine “Syncarcinogenese” vor.

Summary

Droplet application of urethan to the skin of C 57 black mice (single dose: 11.2 mg; total dosage: 1560 mg/animal) led chiefly (84%) to hepatic “blood cysts”, and in one animal (2%) to a squamous cell carcinoma locally at the site of application. The cutaneous droplet application of 9,10-dimethyl-1,2-benzanthracene (single dose: 0.0018 mg; total dosage: 0.0504 mg/animal) caused skin carcinomas in 9.5% of the animals. When both substances were applied together to the skin in the same dosage as above, the number of tumors induced was not increased. No “syncarcinogenesis” existed.

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Author information

Authors and Affiliations

  1. Pathologischen Institut der Universität Bonn, Bonn, Deutschland

    D. Schmähl, C. Thomas & H. Brune

  2. biologischen Laboratorium des Vaselinwerks, Hamburg

    D. Schmähl, C. Thomas & H. Brune

Authors
  1. D. Schmähl
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  2. C. Thomas
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  3. H. Brune
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Additional information

Herrn Prof. Dr. Hamperl, Bonn, zum 65. Geburtstag gewidmet.

Mis Unterstützung der Deutschen Forschungsgemeinschft.

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Schmähl, D., Thomas, C. & Brune, H. Experimentelle Untersuchungen zur Syncarcinogenese. Z Krebs-forsch 66, 297–302 (1964). https://doi.org/10.1007/BF00524158

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  • DOI: https://doi.org/10.1007/BF00524158

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