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Synthesis, structure, and biological properties of N-oxides of some 2-substituted quinoxalines and pyrazines

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Chemistry of Heterocyclic Compounds Aims and scope

Abstract

2-Methoxy- and 2-hydroxy-substituted quinoxaline and pyrazine N,N′-dioxides and N-oxides of a number of quinoxaline-2-carboxylic acid derivatives were synthesized in order to study their biological activity. It is shown that the N-monoxides and N,N′-dioxides of 2-hydroxy derivatives of quinoxaline exist primarily in the oxo form. Strong intramolecular hydrogen bonds were detected in the case of 1-N-oxides of 2-hydroxy and 2-carboxamido derivatives of quinoxaline. Substances with antibacterial and antituberculous activity were found among the synthesized compounds.

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Authors and Affiliations

  1. S. Ordzhonikidze All-Union Scientific-Research Pharmaceutical-Chemistry Institute, Moscow

    A. S. Elina, I. S. Musatova, E. M. Peresleni & E. N. Padeiskaya

Authors
  1. A. S. Elina
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  2. I. S. Musatova
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  3. E. M. Peresleni
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  4. E. N. Padeiskaya
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 2, pp. 278–283, February, 1976.

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Elina, A.S., Musatova, I.S., Peresleni, E.M. et al. Synthesis, structure, and biological properties of N-oxides of some 2-substituted quinoxalines and pyrazines. Chem Heterocycl Compd 12, 239–244 (1976). https://doi.org/10.1007/BF00523980

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  • DOI: https://doi.org/10.1007/BF00523980

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