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Esterification of pyridinecarboxylic acids in the presence of cation-exchange resins

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Chemistry of Heterocyclic Compounds Aims and scope

Abstract

Pyridinecarboxylic acids undergo esterification on refluxing with alcohols in the presence of cation-exchange resins. In the case of pyridine-2,6-dicarboxylic acid, in which the basicity of the nitrogen atom is reduced, esterification products are obtained in high yields. In the case of pyridinecarboxylic acids, in which the pyridine nitrogen atom displays considerable basicity, the cations of the acids are tied up by the cation-exchange resin, and the yields of preparatively isolable esters do not exceed 60%.

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Authors and Affiliations

  1. S. Ordzhonikidze All-Union Scientific-Research Pharmaceutical-Chemistry Institute, Moscow

    E. I. Levkoeva, L. I. Mastafanova, D. M. Krasnokut-skaya, M. I. Evstratova, Ya. S. Karpman, I. S. Tubina, I. L. Ivanova & L. N. Yakhontov

Authors
  1. E. I. Levkoeva
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  2. L. I. Mastafanova
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  3. D. M. Krasnokut-skaya
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  4. M. I. Evstratova
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  5. Ya. S. Karpman
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  6. I. S. Tubina
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  7. I. L. Ivanova
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  8. L. N. Yakhontov
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Additional information

Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 2, pp. 233–237, February, 1976.

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Levkoeva, E.I., Mastafanova, L.I., Krasnokut-skaya, D.M. et al. Esterification of pyridinecarboxylic acids in the presence of cation-exchange resins. Chem Heterocycl Compd 12, 201–204 (1976). https://doi.org/10.1007/BF00523971

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  • DOI: https://doi.org/10.1007/BF00523971

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