Summary
A study has been made on the distribution of non-specific esterase within the cerebellar anlage in mouse during development. A weak positive reaction has been revealed in the neural tube even in a 9 days old embryo (neuromeric phase). During the further development of the cerebellum, only a weak, homogeneous positive reaction can be seen up to about 17 days old embryos. From this stage onwards, a strong positive reaction is found in the deep cerebellar nuclei, which stand out clearly against the pale background. Within the cerebellar cortex only a relatively weak positive reaction can be seen. It is suggested that the strong reactivity of the deep cerebellar nuclei may also be of importance in the morphological delimitation of these nuclei in advanced developmental stages.
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Bernsohn, J., K. D. Barron, A. R. Hess, and M. T. Hedrick: Alterations in properties and isoenzyme patterns of esterases in developing rat brain. J. Neurochem. 10, 783–794 (1963).
Borghese, E.: Recent histochemical results of studies on embryos of some birds and mammals. Int. Rev. Cytol. 6, 289–341 (1957).
Colmant, H.-J.: Ergebnisse der Enzymhistochemie am zentralen und peripheren Nervensystem. Fortschr. Neurol. Psychiat. 29, 61–124 (1961).
Gomori, G., and R. D. Chessick: Esterases and phosphatases of the brain. A histochemical study. J. Neuropath. exp. Neurol. 12, 387–396 (1953).
Källén, B., and B. Lindskog: Formation and disappearance of neuromery in Mus musculus. Acta anat. (Basel) 18, 273–282 (1953).
McKay, D. G., E. C. Adams, A. T. Hertig, and S. Danziger: Histochemical horizons in human embryos. I. Five millimeter embryo-Streeter Horizon XIII. Anat. Rec. 122, 125–151 (1955).
Moog, F.: The distribution of phosphatase in the spinal cord of chick embryos of one to eight days' incubation. Proc. nat. Acad. Sci. (Wash.) 29, 176–183 (1943).
—: Localizations of alkaline and acid phosphatases in the early embryogenesis of the chick. Biol. Bull. 86, 51–80 (1944).
Pearse, A. G. E.: Functional histochemistry of hypothalamic neurons. Proc. II int. Congr. neuropath. London 1, 601–605 (1955).
—: Histochemistry, theoretical and applied, 2. ed. London: J. & A. Churchill Ltd. 1960.
Reale, E.: Sulle attività esterasiche durante lo sviluppo prenatale dei roditori: Recerche in Mus musculus albinus. Riv. istochim. 1 (5), 551–566 (1955).
Rossi, F.: In: Handbuch der Histochemie, Enzyme, Bd. VII, Teil 4. Stuttgart: Gustav Fischer 1964.
—, G. Pescetto e E. Reale: La fosfatasi acida nelle attività enzimatiche operanti nell' organogenesi dell'uomo. Monit. zool. ital., Suppl. 60, 305–306 (1951).
———: Enzymatic activities in human ontogenesis: First synoptic tables of histochemical research. J. Histochem. Cytochem. 5, 221–235 (1957).
Rüdeberg, S. I.: Morphogenetic studies on the cerebellar nuclei and their homologization in different vertebrates including man. Thesis Lund 1961.
Seligman, A. M.: Contribution to a discussion. J. nat. Cancer Inst. 12, 245 (1951).
Tewari, H. B., and G. H. Bourne: Histochemical studies on the distribution of specific and non-specific cholinesterases and simple esterase in the cerebellum of the rat. Acta anat. (Basel) 51, 349–368 (1962).
Zacks, S. J.: Esterases in the early chick embryo. Anat. Rec. 118, 509–537 (1954).
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Rüdeberg, SI. Topographic distribution of non-specific esterase during cerebellar development in mouse. Z. Anat. Entwickl. Gesch. 124, 226–233 (1964). https://doi.org/10.1007/BF00523581
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DOI: https://doi.org/10.1007/BF00523581