Skip to main content
Log in

Amine im menschlichen Stuhl

II. Bestimmung des p-Tyramingehaltes in Stühlen von Kindern verschiedener Altersklassen

  • Published:
Zeitschrift für Kinderheilkunde Aims and scope Submit manuscript

Zusammenfassung

Die p- und m-Tyraminausscheidung wurde quantitativ im Stuhl von Neugeborenen, Säuglingen und Schulkindern unter verschiedenen Kostformen untersucht. Der p-Tyramingehalt von normalen Säuglingsstühlen (Naßgewicht) lag zwischen 0,030–0,460 μMol/g Stuhl, der normaler Stühle von Schulkindern zwischen 0,005 und 0,102 μMol/g Stuhl. m-Tyramin ließ sich in Säuglingsstühlen nicht nachweisen. Die Konzentration im Stuhl von Schulkindern überschritt sicher nicht 0,008 μMol/g Stuhl.

Summary

The excretion of para- and meta-tyramine in faeces was estimated in newborns, infants, and children during the application of various diets. The p-tyramine content of normal stools of infants (wet weight) amounted 0.030–0.460 μmoles per gr. faeces and that of children 0.005–0.102 μmoles per gr. m-Tyramine was not detected in the faeces of infants. If this substance is found at all in faeces of children it does not exceed 0.008 μmoles per gr. of faeces.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Literatur

  1. Awapara, J., T. L. Perry, C. Hanly, and E. Peck: Substrate specificity of DOPA decarboxylase. Clin. chim. Acta 10, 286 (1964).

    Google Scholar 

  2. Bray, H. G., W. V. Thorpe, and K. White: The fate of certain organic acids and amides in the rabbit. 10. The application of paper chromatography to metabolic studies of hydroxybenzoic acids and amides. Biochem. J. 46, 271 (1950).

    Google Scholar 

  3. Bremer, H. J., u. H. Dengler: Amine im menschlichen Stuhl. I. Untersuchungen über das Vorkommen von Oxyphenyläthylaminen in normalen Säuglings- und Kinderstühlen. Z. Kinderheilk. 97, 264 (1966).

    Google Scholar 

  4. Bremer, H. J. and U. Jaenicke: The excretion of phenolic amines in premature babies with hypertyrosinemia. (In preparation.)

  5. Gale, E. F.: The bacterial amino acid decarboxylases. Advanc. Enzymol. 6, 1 (1946).

    Google Scholar 

  6. Hartmann, F., u. H. Lenz: Das Phenol- und Indolmuster des Rattenurins nach Verfütterung von Tyrosin, Tryptophan und Phenylalanin und nach Hemmung der Darmflora durch Neomycin. Deutsch. Arch. klin. Med. 208, 29 (1962).

    Google Scholar 

  7. Hooft, C., J. Timmermans, J. Snoeck, I. Antener, W. Oyaert, and Ch. van den Hende: Methionine malabsorption syndrome. Ann. paediat. (Basel) 205, 73 (1965).

    Google Scholar 

  8. Horwitz, D., W. Lovenberg, K. Engelman, and A. Sjoerdsma: Monoamine oxidase inhibitors, tyramine, and cheese. J. Amer. med. Ass. 188, 1108 (1964).

    Google Scholar 

  9. Jepson, J. B., W. Lovenberg, P. Zaltzman, J. A. Oates, A. Sjoerdsma, and S. Udenfriend: Amine metabolism. Studied in normal and phenylketonuric humans by monoamine oxidase inhibition. Biochemie J. 74, 5 P (1960).

    Google Scholar 

  10. Kakimoto, Y., and M. D. Armstrong: The phenolic amines of human urine. J. biol. Chem. 237, 208 (1962).

    Google Scholar 

  11. ——: On the identification of octopamine in mammals. J. biol. Chem. 237, 422 (1962).

    Google Scholar 

  12. Melnykowycz, J., and K. R. Johansson: Formation of amines by intestinal microorganisms and the influence of chlortetracycline. J. exp. Med. 101, 507 (1955).

    Google Scholar 

  13. Milne, M. D., A. M. Asatoor, K. D. G. Edwards, and L. W. Loughridge: The intestinal absorption defect in cystinuria. Gut 2, 323 (1961).

    Google Scholar 

  14. —, M. A. Crawford, C. B. Girao, and L. W. Loughridge: The metabolic disorder in Hartnup disease. Quart. J. Med. 29, 407 (1961).

    Google Scholar 

  15. Mitoma, C., H. S. Posner, D. F. Bogdanski, and S. Udenfriend: Biochemical and pharmacological studies on o-tyrosine and its meta and para analogues. A suggestion concerning phenylketonuria. J. Pharmacol. exp. Ther. 120, 188 (1957).

    Google Scholar 

  16. Myhrman, G., u. J. Tomenius: Über das Vorkommen von Histamin in menschlichen Faeces. Naunyn-Schmiedebergs Arch. exp. Path. Pharmak. 193, 14 (1939).

    Google Scholar 

  17. Perry, T. L., S. Hansen, M. Hestrin, and L. MacIntyre: Exogenous urinary amines of plant origin. Clin. chim. Acta 11, 24 (1965).

    Google Scholar 

  18. Schenker, V., and A. C. Schenker: Studies on human saliva: A tyramine like component and its response to autonomic stimulation. J. Nerv. ment. Dis. 128, 520 (1959).

    Google Scholar 

  19. Smith, I.: Chromatographic and electrophoretic techniques, p. 97. London: Heinemann 1960.

    Google Scholar 

  20. Udenfriend, S.: In Methods in Enzymology, Vol. III, p. 611. Ed.: S. P. Colowick, and N. O. Kaplan. New York: Academic Press 1957.

    Google Scholar 

  21. Udránsky, L. v., u. E. Baumann: Über das Vorkommen von Diaminen, sogenannten Ptomainen, bei Cystinurie. Hoppe-Seylers Z. physiol. Chem. 13, 562 (1889).

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Additional information

Mit Unterstützung durch die Deutsche Forschungsgemeinschaft.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Bremer, H.J. Amine im menschlichen Stuhl. Z. Kinder-Heilk. 97, 275–280 (1966). https://doi.org/10.1007/BF00523277

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00523277

Navigation