Chemistry of Heterocyclic Compounds

, Volume 19, Issue 6, pp 644–650 | Cite as

Opening of the three-membered ring in 1,1-disubstituted cyclopropanes as a method for the synthesis of functional derivatives of pyrazole and isoxazole

  • N. S. Zefirov
  • S. I. Kozhushkov
  • T. S. Kuznetsova


The reaction of 1,1-diacylcyclopropanes with hydrazine and hydroxylamine derivatives, which leads to nucleophilic opening of the three-membered ring and the formation of pyrazole and isoxazole derivatives, was studied. The dependence of the occurrence of this reaction on the structure of the diketo derivatives of the cyclopropane series was investigated.


Organic Chemistry Hydrazine Pyrazole Cyclopropane Hydroxylamine 
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Copyright information

© Plenum Publishing Corporation 1983

Authors and Affiliations

  • N. S. Zefirov
    • 1
  • S. I. Kozhushkov
    • 1
  • T. S. Kuznetsova
    • 1
  1. 1.M. V. Lomonosov Moscow State UniversityMoscow

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