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Epitheloide Fibroblasten im Endometrium des Schafes

Epitheloid fibroblasts of the sheep endometrium

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Summary

During gravidity grow the fibroblasts of the subepitheliar paraplacental connective tissue of the sheep uterus into polyhedral, epithelium—like cells forming a distinct layer. This transformation is characterized by a narrowing of the intercellular spaces, an increase in the number of junctional specialisations and pinocytotic vesicles, the appearance of membrane interdigitations, of smooth endoplasmic reticulum, of numerous, frequently large lysosomes, and by the enlargement of the Golgi complex. The physiological significance of this transformation appears to be an improvement in the transport of substances to the fetus via the paraplacental tissue. With respect to their ultrastructural appearance, the changes resemble those of the early stages of decidua formation in man and in rodents.

Zusammenfassung

Die subepithelialen Fibroblasten des Schafendometriums wandeln sich im paraplacentaren Bereich nach etwa 7 Wochen Graviditätsdauer in ein kompaktes Lager epitheloider Zellen um. Charakteristisch sind dabei die Verengung der Intercellularräume, Vermehrung von Hafteinrichtungen und Mikropinocytosevorgängen, das Auftreten von flächenhaften Membraninterdigitationen und glattem endoplasmatischem Reticulum, sowie zahlreichen, z. T. sehr großen Lysosomen und eine Vergrößerung der Golgiapparate. Gedeutet werden diese Befunde als Spezialisierung für trophische Aufgaben. Die Vorgänge erinnern ultrastrukturell an frühe Dezidualisierungsstadien von Mensch und Nagetieren.

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Künzel, E., Tiedemann, K. Epitheloide Fibroblasten im Endometrium des Schafes. Z. Anat. Entwickl. Gesch. 136, 336–347 (1972). https://doi.org/10.1007/BF00522621

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