Abstract
The chlorination of 4-phenyl-2,3-dihydro-1H-1,5-benzodiazepin-2-one with N-chlorosuccinimide takes place at the methylene group to give mono and diehloro derivatives. In the reaction of the diazepinone with sulfuryl chloride chlorine is incorporated in the 1 or 3 position or in both the 1 and 3 positions, as well as in the para position of the phenyl substituent; in the presence of anhydrous aluminum chloride substitution takes place in the methylene group of the heteroring and in the 8 position of the annelated benzene ring.
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 3, pp. 405–409, March, 1982.
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Solomko, Z.F., Sheremet, V.I., Khmel', M.P. et al. Chloro derivatives of 4-phenyl-2,3-dihydro-1H-1,5-benzodiazepin-2-one. Chem Heterocycl Compd 18, 307–310 (1982). https://doi.org/10.1007/BF00522136
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DOI: https://doi.org/10.1007/BF00522136