Summary
Time of origin of various neuronal elements in the cerebellum of rat was established with the aid of tritiated-thymidine-autoradiography. The earliest nerve cells to form were the Purkinje cells, and they came into existence on days 15 and 16 of gestation. Interstitial nerve cells had their genesis on days 15, 16, 17 and 18, and the marginal cells on day 16 of the embryonic development. The Golgi cells were found to come into existence on days 17, 18 and 19 of gestation. On day 21 of gestation a number of small-medium-sized nerve cells, which were smaller than the Golgi cells but larger than the granule cells, were seen to come into existence. Finally, the earliest stock of granule, basket and stellate cells, primarily in the nodulus, flocculus and para-flocculus, were observed to have been formed on the day 21 of embryogenesis.
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This research was supported by NIH Research Grant No. NS-08817-03. Histological work by Sheila Anderson and photographic work by Donna Whitehurst is gratefully acknowledged.
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Das, G.D., Nornes, H.O. Neurogenesis in the cerebellum of the rat: An autoradiographic study. Z. Anat. Entwickl. Gesch. 138, 155–165 (1972). https://doi.org/10.1007/BF00519378
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DOI: https://doi.org/10.1007/BF00519378