, Volume 87, Issue 1, pp 91–96 | Cite as

The morphogenesis of the human Paneth cell

An immunocytochemical ultrastructural study
  • M. Mathan
  • J. Hughes
  • R. Whitehead


In human duodenal mucosa Paneth cells originate away from the base of crypts and migrate towards the base during maturation The earliest cells in the Paneth cell lineage could be identified by labelling of lysozyme in the Golgi apparatus. Specific labelling for lysozyme was present in the rough endoplasmic reticulum, Golgi apparatus, condensing vacuoles, granules and many lysosomes of mature Paneth cells. The maturation of the Paneth cell is accompanied by an increase in the content of lysozyme in the secretory granules and with senescence lysozyme diffuses into the cytoplasm.


Public Health Endoplasmic Reticulum Lysozyme Golgi Apparatus Secretory Granule 
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  1. Bjerknes M, Cheng H (1981) The stem-cell zone of the small intestinal epithelium. I. Evidence from Paneth cells in the adult mouse. Am J Anat 160:51–63Google Scholar
  2. Bosman FT (1983) Some recent developments in immunocytochemistry. Histochem J 15:189–200Google Scholar
  3. Cheng H (1974) Origin, differentiation and renewal of the four main epithelial cell types in the mouse small intestine. IV. Paneth cells. Am J Anat 141:521–536Google Scholar
  4. Cheng H, Leblond CP (1974) Origin, differentiation and renewal of the four main epithelial cell types in the mouse small intestine. V. Unitarian theory of the origin of the four epithelial cell types. Am J Anat 141:537–562Google Scholar
  5. Creamer B (1967) Paneth-cell function. Lancet 1:314–315Google Scholar
  6. De Duve C (1969) The lysosome, in retrospect. In: Dingle JT, Fell HB (eds) Lysosomes in biology and pathology. North-Holland, Amsterdam, pp 3–40Google Scholar
  7. Elmes ME, Stanton MR, Howells, CHL, Lowe GH (1984) Relation between the mucosal flora and Paneth cell population of human jejunum and ileum. J Clin Pathol 37:1268–1271Google Scholar
  8. Erlandsen SL, Parsons JA, Taylor TD (1974) Ultrastructural immunocytochemical localization of lysozyme in the Paneth cells of man. J Histochem Cytochem 22:401–413Google Scholar
  9. Frens G (1973) Controlled nucleation for the regulation of the particle size in monodisperse gold suspensions. Nature (Phys Sci) 241:20–22Google Scholar
  10. Grube D (1980) Immunoreactivities of gastrin (G-) cells. Histochemistry 66:149–167Google Scholar
  11. Lopez-Lewellyn, J, Erlandsen SL (1980) Cytodifferentiation of the rat Paneth cell: An immunocytochemical investigation in suckling and weanling animals. Am J Anat 158:285–297Google Scholar
  12. Mathan M, Mathan VI (1985) Rectal mucosal morphologic abnormalities in normal subjects in Southern India: A tropical colonopathy? Gut 26:710–717Google Scholar
  13. Montero C, Erlandsen SL (1978) Immunocytochemical and histochemical studies on intestinal epithelial cells producing both lysozyme and mucosubstance. Anat Rec 190:127–142Google Scholar
  14. Rodning CB, Wilson ID, Erlandsen SL (1976) Immunoglobulins within human small-intestinal paneth cells. Lancet 1:984–987Google Scholar
  15. Sandow MJ, Whitehead R (1979) The Paneth cell: Progress report. Gut 20:420–431Google Scholar
  16. Spicer SS, Frayser R, Virella G, Hall BJ (1977) Immunocytochemical localization of lysozymes in respiratory and other tissues. Lab Invest 36:282–294Google Scholar
  17. Subbuswamy SG (1973) Paneth cells and goblet cells. J Pathol 111:181–191Google Scholar
  18. Trier JS, Madara JL (1981) Functional morphology of the mucosa of the small intestine. In: Johnson LR (ed) Physiology of the gastrointestinal tract. Raven Press, New York, pp 925–961Google Scholar
  19. Trier JS, Lorenzsonn V, Grochler K (1967) Pattern of secretion of paneth cells of the small intestine of mice. Gastroenterology 53:240–248Google Scholar

Copyright information

© Springer-Verlag 1987

Authors and Affiliations

  • M. Mathan
    • 1
  • J. Hughes
    • 2
  • R. Whitehead
    • 2
  1. 1.The Wellcome Research UnitChristian Medical College HospitalVelloreIndia
  2. 2.Department of PathologyFlinders Medical CentreBedford ParkSouth Africa

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