Histochemistry

, Volume 87, Issue 1, pp 91–96 | Cite as

The morphogenesis of the human Paneth cell

An immunocytochemical ultrastructural study
  • M. Mathan
  • J. Hughes
  • R. Whitehead
Article

Summary

In human duodenal mucosa Paneth cells originate away from the base of crypts and migrate towards the base during maturation The earliest cells in the Paneth cell lineage could be identified by labelling of lysozyme in the Golgi apparatus. Specific labelling for lysozyme was present in the rough endoplasmic reticulum, Golgi apparatus, condensing vacuoles, granules and many lysosomes of mature Paneth cells. The maturation of the Paneth cell is accompanied by an increase in the content of lysozyme in the secretory granules and with senescence lysozyme diffuses into the cytoplasm.

Keywords

Public Health Endoplasmic Reticulum Lysozyme Golgi Apparatus Secretory Granule 

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Copyright information

© Springer-Verlag 1987

Authors and Affiliations

  • M. Mathan
    • 1
  • J. Hughes
    • 2
  • R. Whitehead
    • 2
  1. 1.The Wellcome Research UnitChristian Medical College HospitalVelloreIndia
  2. 2.Department of PathologyFlinders Medical CentreBedford ParkSouth Africa

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