Summary
The opaques droplets Nishiura in the Virchow-lepracell could be regarded as lysosom. In the reactionsloose lepromatous leprosy the lysosomes stand still long time. Then lamellated, foliated structures appear which are residualbodies of lysosomes. Evidently spiral, double conturated membransystem incorporate in such structures. These membransystems may be come from endoplasmatic reticulum.
Zusammenfassung
In der Virchowschen Leprazelle können die opaken Tropfen Nishiuras heute als Lysosomen angesehen werden. Bei der reaktionslosen lepromatösen Lepra bleiben die Lysosomen mit degenerierten Erregern offensichtlich lange Zeit liegen. Dann treten lamellierte, blättrige Strukturen auf, die den Residualkörpern der Lysosomen entsprechen. Offenbar können in solche Strukturen spiralige doppelkonturierte Membransysteme einbezogen werden, die nur vom endoplasmatischen Reticulum abstammen können.
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Literatur
Anders, K. H., u. G. Nielsen: Beobachtungen an Adenovirus (Typ 3)-infizierten HeLa-Zellkulturen nach Fixierung mit Kaliumpermanganat. IV. Int. Conf. Electron Microscopy, Berlin, S. 602–605. Berlin, Göttingen, Heidelberg: Springer 1960.
Blinzinger, K., u. H. Hager: Elektronenmikroskopische Befunde zur Struktur und Entstehung von Riesenlysosomen in Makrophagen bei Spätläsionen einer experimentell erzeugten bakteriellen Meningitis. Naturwissenschaften 48, 480–481 (1961).
Brewer, D. B.: Electron microscopy of phagocytosis of staphylococci. J. Path. Bact. 8, 299–303 (1963).
Brieger, E. M., and J. M. Allen: Cytopathological changes in lepra cells. Exp. Cell. Res. 28, 438–440 (1962).
——: The submicroscopical structure of mycobacterium leprae and the cell of Virchow (lepra cell). In: Cochrane and Davey: Leprosy in theory and practice. Bristol: John Wright & Sons Ltd. 1964.
Cedergren, B.: The lung tissue in mice infected by tubercle bacilli. Electronmicroscopy Proc. Stockholm Conf. Sept. 1956. Almqvist and Wilksell, 248–249.
Cohen, A. S.: An electron microscopic study of the structure of the small intestine in Whipple's disease. J. Ultrastruct. Res. 10, 124–144 (1964).
Imaeda, T.: Electron-microscopic study of xanthoma cells. J. invest. Derm. 43, 331–337 (1960).
—: Electron microscopy. Approach to leprosy research. Int. J. Leprosy 33, 669–688 (1965).
— J. Convit, S. Mendoza, and J. Arvelo: Electron microscope study of xanthoma cells in a lepromatous leprosy lesion. Int. J. Leprosy 29, 343–354 (1961).
Friedmann, I.: Pleomorphic cytoplasmic inclusion bodies in tissue cultures of the otocyst esposed to dimycin. IV Int. Conf. Electron Microscopy Berlin, p. 266 to 269. Berlin, Göttingen, Heidelberg: Springer 1960.
Gedigk, P., u. E. Bontke: Über den Nachweis von hydrolytischen Enzymen in Lipopigmenten. Z. Zellforsch. 44, 495–518 (1956).
Herman, L., P. J. Fitzgerald, M. Weiss, and I. S. Polevoy: Electronmicroscopy observations of degenerating and regenerating pancreas following ethionine administration. IV. Int. Conf. Electron Microscopy, Berlin, Göttingen, Heidelberg 373–378. Berlin, p.: Springer 1960.
Kalkoff, K. W., u. K. H. Holtz: Zur Mikromorphologie des intracytoplasmatischen Lipopigments (Ceroid) bei Sarkoidose und anderen Granulomen. Hautarzt 15, 544–548 (1964).
Klingmüller, G., u. C. Orfanos: Der elektronenmikroskopische Aufbau des Mycobacterium leprae. Arch. klin. exp. Derm. (im Druck).
Kölbel, H.: Über das em. beobachtete Auftreten molekular assoziierter Fettsäuren bei Mycobacterium avium. Jahresbericht Borstel V 282–302 (1961).
Kojima, K., and S. Kosuka: Structural changes in HeLa-cells cultivated in serumfree medium. J. Cell. Biol. 14, 141–144 (1962).
Menefee, M. G., and V. J. Evans: Structural differences produced in mammalian cells by changes in their environment. J. Nat. Cancer Inst. 25, 1303–1324 (1960).
Mercer, E. H.: Comparison of natural biological membranes with artificial models. In: Electron microscopy in anatomy, p. 100–113. London: Edward Arnold Ltd. 1961.
Merckx, J. J., A. L. Brown, and A. G. Karlson: An electronmicroscopic study of experimental infections with acid-fast bacilli. Amer. Rev. resp. Dis. 89, 485–496 (1964).
Merker, H. J.: Die Lysosomen, eine neue Zellorganellgruppe. Berlin. Med. 15, 247–244 (1964).
—: Structur und Funktion der Lysosomen. Materia Medica Nordmark 17, 684–699 (1965).
Nelson, E., K. Blinzinger u. H. Hager: An electron microscopic study of bacterial meningitis. Arch. Neurol. (Chic.) 6, 390–403 (1962).
———: Ultra-structural observation an phagocytosis of bacterial in experimental (E. coli) meningitis. J. Path. exp. Neurol. 21, 155–169 (1962).
Nishiura, M.: The electron microscopic basis of the pathology of leprosy. Int. J. Leprosy 28, 357–400 (1960).
—: A study of the relationship between the ultrastructures of leprosy lesions and their responsiveness to the antileprosy treatment. La Lepro 32, 86–87 (1963).
— N. Harade, and T. Imaeda: Electronmicroscopy of ultrathin section of lepromatous peripheral nerves. Int. J. Leprosy 25, 323–328 (1957).
— J. Ogawa, F. Kanesuma, E. Toda, and N. Isowa: Myelinic figures in lepra-cells examined by phasecontrast and electron-microscopy. Int. J. Leprosy 32, 45–52 (1964).
Nunez, O., J. Weibel, and J. Vitelli-Flores: Electron microscopy study of the cytopathology of ECHO-virus infection in cultivated cells. J. biophys. biochem. Cytol. 11, 457–467 (1961).
Policard, A., D. Collet, and S. Pregermain: Etude an microscope electronique de la lipophanerose cytoplasmique. IV. Int. Conf. Electron Microscopy Berlin, p. 258–261. Berlin, Göttingen, Heidelberg: Springer 1960.
Schulz, H.: Die Submikroskopische Anatomie und Pathologie der Lunge. Berlin, Göttingen, Heidelberg: Springer 1959.
Tanaka, H.: Segresome and the cellular uptake of varied substances as reyealed in the electron microscope. Ann. Rept. Inst. Virus Res. Kyoto University 1961, 118–152.
Wade, H. W.: The Lysosomes. Int. J. Leprosy 33, 351–355 (1965).
Yamamoto, T., M. Nishiura, N. Harada, and T. Imaeda: Electron microscopy of mycobacterium leprae murium in ultrathin sections of murine leprosy lesions. Int. J. Leprosy 26, 111–114 (1958).
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Klingmüller, G. Residualkörper bei lepromatöser Lepra. Arch. klin. exp. Derm. 225, 149–162 (1966). https://doi.org/10.1007/BF00518107
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DOI: https://doi.org/10.1007/BF00518107