Naunyn-Schmiedeberg's Archives of Pharmacology

, Volume 292, Issue 3, pp 289–293 | Cite as

Anti-dopaminergic and anti-muscarinic effects of dibenzodiazepines

Relationship to drug induced parkinsonism
  • R. J. Miller
  • C. R. Hiley


  1. 1.

    The anti-dopaminergic effects of several dibenzodiazepines were examined on the dopaminestimulated adenylate cyclase in rat striatal homogenates. The “cis” isomer of clozapine, HF-2046, was the most potent in this respect and perlapine, which is devoid of neuroleptic activity, was the weakest.

  2. 2.

    The anti-muscarinic effects of the same compounds were measured by using the muscarinic affinity label 3H-propylbenzilylcholine mustard. HF-2046 was the most potent and loxapine the least potent of the drugs used.

  3. 3.

    The anti-dopaminrgic effects of the drugs correlate well with neuroleptic but not with extrapyramidal effects. The anti-dopaminergic/anti-muscarinic ratio, however, correlates well with extrapyramidal rather than neuroleptic effects.


Key words

Clozapine Dibenzodiazepines Dopamine Muscarinic receptors Parkinsonism 


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Copyright information

© Springer-Verlag 1976

Authors and Affiliations

  • R. J. Miller
    • 1
  • C. R. Hiley
    • 2
  1. 1.M. R. C. Neurochemical Pharmacology Unit, Department of PharmacologyMedical SchoolCambridgeUK
  2. 2.Department of Pharmacology and TherapeuticsUniversity of LiverpoolLiverpoolUK

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