Summary
Ferrihemoglobin formation by nitrosobenzene and p-, m- and o-aminophenol was studied in erythrocyte suspensions from a number of avian and mammalian species. Compared with the mammalian erythrocytes, bird red cells show little species differences in susceptibility. In birds, dose-effect relationships are different for nitrosobenzene and the aminophenols: using low concentrations nitrosobenzene is more active than the aminophenols, while at higher concentrations o-aminophenol is at least equally effective. In birds, o-aminophenol is about eight times more potent than p-aminophenol. m-Aminophenol is not an inducer of ferrihemoglobin in erythrocytes of the cat, the goat and the Japanese quail.
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Blaauboer, B. J., van Holsteijn, C. W. M., Wit, J. G.: Nitrosobenzene-induced ferrihemoglobin formation in Japanese quail erythrocytes. The significance of ferrihemoglobin reduction. Naunyn-Schmiedeberg's Arch. Pharmacol. 289, 127–135 (1975)
Debackere, M., Uehleke, H.: C- and N-hydroxylation of aromatic amines by isolated liver microsomes of different species. Proc. Eur. Soc. Study Drug Toxicity IV, 40–45 (1964)
Eyer, P., Kiese, M., Lipowsky, G., Weger, N.: Reactions of 4-dimethylaminophenol with hemoglobin and autoxidation of 4-dimethylaminophenol. Chem.-Biol. Interactions 8, 41–59 (1974)
Kiese, M.: Oxydation von Anilin zu Nitrosobenzol im Hunde. Naunyn Schmiedebergs Arch. exp. Path. Pharmak. 235, 354–359 (1959)
Kiese, M.: Methemoglobinemia: A comprehensive treatise, pp. 80–83. Cleveland: CRC Press 1974
Kiese, M., Pekis, M.: The reaction of p-aminophenol with hemoglobin and oxygen in vivo and in vitro. Naunyn-Schmiedebergs Arch. exp. Path. Pharmak. 246, 413–420 (1964)
Kiese, M., Rachor, M.: The reaction of several aminophenols with hemoglobin and oxygen in vitro and in vivo. Naunyn-Schmiedebergs Arch. exp. Path. Pharmak. 249, 225–236 (1964)
Parke, D. V.: Studies in detoxication: 84. The metabolism of (14C) aniline in the rabbit and other animals. Biochem. J. 77, 493–503 (1960)
Parke, D. V., Williams, R. T.: Species differences in the o- and p-hydroxylation of aniline. Biochem. J. 63, 12p (1956)
Parke, D. V., Williams, R. T.: The hydroxylation of foreign aromatic compounds in the animal body. Ann. reports chem. soc. for 1958, 55, 376–388 (1959)
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Blaauboer, B.J., van Holsteijn, C.W.M. & Wit, J.G. Ferrihemoglobin formation by monohydroxy aniline derivatives in erythrocytes of some avian species in comparison with mammals. Naunyn-Schmiedeberg's Arch. Pharmacol. 292, 255–258 (1976). https://doi.org/10.1007/BF00517386
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DOI: https://doi.org/10.1007/BF00517386