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Polymorphonuclear and mononuclear leucocyte function in necrobiosis lipoidica and granuloma annulare

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Summary

Neutrophils and monocytes from patients with necrobiosis lipoidica (NL) and granuloma annulare (GA) were studied in vitro in order to detect functional abnormality. Phagocytosis of latex particles and zymosan-induced release of β-glucuronidase were similar in patients and controls. Plasma from these patients did not enhance or inhibit phagocytosis or enzyme release from normal cells. Our studies suggest that peripheral blood leucocyte function in patients with GA and NL is normal, but this does not exclude a functional abnormality in the lesions.

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Authors and Affiliations

  1. Department of Dermatology, St. Helier Hospital, SM5 1AA, Carshalton, Surrey, UK

    M. S. Koh, B. B. J. Majewski, S. Barter & E. L. Rhodes

Authors
  1. M. S. Koh
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  2. B. B. J. Majewski
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  3. S. Barter
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  4. E. L. Rhodes
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Supported by the South West Thames Regional Health Authority

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Koh, M.S., Majewski, B.B.J., Barter, S. et al. Polymorphonuclear and mononuclear leucocyte function in necrobiosis lipoidica and granuloma annulare. Arch Dermatol Res 275, 45–47 (1983). https://doi.org/10.1007/BF00516554

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  • DOI: https://doi.org/10.1007/BF00516554

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